Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study.
Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study.
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DOI：
10.1161/hypertensionaha.108.127043
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Kritchevsky SB
中科院分区：
文献类型：
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作者：
Brinkley TE;Nicklas BJ;Kanaya AM;Satterfield S;Lakatta EG;Simonsick EM;Sutton-Tyrrell K;Kritchevsky SB
动脉硬化是血管老化的一个显著特征，与心血管疾病（CVD）密切相关。氧化低密度脂蛋白（ox-LDL）是动脉粥样硬化发病机制中的关键因素，也可能在动脉硬化中发挥作用，但这种关系尚未得到很好的研究。因此，我们在社区居住的老年人中研究了ox-LDL和主动脉脉搏波速度（aPWV）（动脉僵硬度的标志物）之间的横截面相关性。在来自健康、衰老和身体组成研究的2,295名参与者（平均年龄74岁; 52%女性; 40%黑人）中测量了血浆ox-LDL水平和aPWV。在ox-LDL的三分位数中，平均aPWV显著增加（三分位数1，869 ± 376 cm/s;三分位数2，901 ± 394 cm/s;三分位数3，938 ± 415 cm/s; p=0.002）。在多变量分析中，在调整人口统计学和传统CVD风险因素后，ox-LDL仍与aPWV相关（p=0.008）。在进一步调整血红蛋白A1 c、腹部内脏脂肪、抗高血压和降血脂药物以及CRP后，与ox-LDL的相关性减弱，但仍具有显著性（p=0.01）。当以绝对量（mg/dL）或相对量（LDL的百分比）表示ox-LDL时，结果相似。此外，最高ox-LDL三分位数的个体有30-55%的可能性患有高动脉硬度，定义为aPWV >第75百分位数（p≤0.02）。总之，我们发现，在老年人中，血浆ox-LDL水平升高与较高的动脉僵硬度相关，独立于CVD危险因素。这些数据表明，ox-LDL可能与动脉硬化的发病机制。
Arterial stiffness is a prominent feature of vascular aging and is strongly related to cardiovascular disease (CVD). Oxidized low-density lipoprotein (ox-LDL), a key player in the pathogenesis of atherosclerosis, may also play a role in arterial stiffening, but this relationship has not been well studied. Thus, we examined the cross-sectional association between ox-LDL and aortic pulse wave velocity (aPWV), a marker of arterial stiffness, in community-dwelling older adults. Plasma ox-LDL levels and aPWV were measured in 2,295 participants (mean age, 74 yrs; 52% female; 40% black) from the Health, Aging and Body Composition study. Mean aPWV significantly increased across tertiles of ox-LDL (tertile 1, 869 ± 376 cm/s; tertile 2, 901 ± 394 cm/s; tertile 3, 938 ± 415 cm/s; p=0.002). In multivariate analyses, ox-LDL remained associated with aPWV after adjustment for demographics and traditional CVD risk factors (p=0.008). After further adjustment for hemoglobin A1c, abdominal visceral fat, anti-hypertensive and antilipemic medications, and CRP the association with ox-LDL was attenuated, but remained significant (p=0.01). Results were similar when ox-LDL was expressed in absolute (mg/dL) or relative amounts (percent of LDL). Moreover, individuals in the highest ox-LDL tertile were 30-55% more likely to have high arterial stiffness, defined as aPWV > 75th percentile (p≤0.02). In conclusion, we found that among elderly persons, elevated plasma ox-LDL levels are associated with higher arterial stiffness, independent of CVD risk factors. These data suggest that ox-LDL may be related to the pathogenesis of arterial stiffness.