ENHANCED RETENTION OF ASBESTOS FIBERS IN THE AIRWAYS OF HUMAN SMOKERS
ENHANCED RETENTION OF ASBESTOS FIBERS IN THE AIRWAYS OF HUMAN SMOKERS
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DOI：
10.1164/ajrccm.151.5.7735593
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发表时间：
1995-05-01
影响因子：
24.7
通讯作者：
STEVENS, B
中科院分区：
文献类型：
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作者：
CHURG, A;STEVENS, B
为了确定香烟烟雾是否会增加石棉的肺部滞留，我们将六名曾接受过大量职业石棉暴露的吸烟者与一组六名具有类似接触但从不吸烟的受试者的气道粘膜中的石棉纤维负荷进行了比较。这些组在年龄、性别、接触年限和平均实质铁石棉负荷方面相匹配。我们发现吸烟者气道粘膜中铁石棉的浓度显着升高（约六倍）（p < 0.02）。两组的温石棉实质负荷在统计学上相似，但吸烟者的温石棉气道负荷再次较高（约 50 倍）（p < 0.006）。两组之间的气道或实质透闪石负荷没有差异。从吸烟者气道粘膜或实质中回收的所有三种石棉纤维都比从不吸烟者回收的纤维短，这一观察结果与实验数据一致，表明香烟烟雾导致较短纤维的保留。这些发现表明，吸烟会导致气道粘膜中铁石棉和温石棉的积累增加。这一过程可能在增强石棉的病理作用方面发挥作用。
To determine whether cigarette smoke increases the pulmonary retention of asbestos, we compared the asbestos-fiber burden in the airway mucosa of six cigarette smokers who had received heavy occupational asbestos exposure with that in a group of six subjects with similar exposure who were never smokers. The groups were matched in terms of age, sex, years of exposure, and mean parenchymal amosite burden. We found that the concentration of amosite in airway mucosa was significantly elevated (by approximately sixfold) in smokers (p < 0.02). Chrysotile parenchymal burdens were statistically similar in both groups, but the chrysotile airway burden was again higher (by approximately 50-fold) in smokers (p < 0.006). There were no differences in airway or parenchymal tremolite burdens between the two groups. Fibers of all three types of asbestos recovered from the airway mucosa or parenchyma of smokers were shorter than fibers recovered from nonsmokers, an observation in accord with experimental data suggesting that cigarette smoke leads to retention of shorter fibers. These findings indicate that cigarette smoking causes enhanced accumulation of both amosite and chrysotile in the airway mucosa. This process may play a role in potentiating the pathologic effects of asbestos.