Phylogeny, classification and evolutionary insights into pestiviruses
Phylogeny, classification and evolutionary insights into pestiviruses
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DOI：
10.1016/j.virol.2008.12.004
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发表时间：
2009-03-15
期刊：
影响因子：
3.7
通讯作者：
Baule, Claudia
中科院分区：
文献类型：
--
作者：
Liu, Lihong;Xia, Hongyan;Baule, Claudia
瘟病毒属包括四个已确定的物种：牛病毒性腹泻病毒 1 (BVDV-1) 和 2 (BVDV-2)、边界病病毒 (BDV) 和猪瘟病毒 (CSFV)；以及一个暂定物种，长颈鹿瘟病毒。已鉴定出其他瘟病毒并建议将其识别为新的亚群/物种。为了获得可靠的系统发育作为瘟病毒分类的基础，通过最大似然和贝叶斯方法分析了 56 个瘟病毒和 2089 个字符的分子数据集，包括 5'UTR、完整的 N-pro 和 E2 基因区域。推断出一个相同、稳健的树拓扑，其中识别出七个得到良好支持的单系进化枝和两个高度分歧的谱系。对主要瘟病毒谱系的最近共同祖先进行了估算，并揭示了它们的进化历史。因此，提出了将瘟病毒分为九种的新建议：BVDV-1、BVDV-2、BVDV-3（非典型牛瘟病毒）、长颈鹿瘟病毒、CSFV、BDV、突尼斯绵羊病毒（TSV；以前称为“突尼斯分离株”）、羚羊病毒和 Bungowannah 病毒。 (c) 2008 Elsevier Inc. 保留所有权利。
The genus Pestivirus comprises four established species: Bovine viral diarrhoea viruses 1 (BVDV-1) and 2 (BVDV-2), Border disease virus (BDV), and Classical swine fever virus (CSFV); and a tentative species, Pestivirus of giraffe. Additional pestiviruses have been identified and suggested for recognition as novel subgroups/species. To achieve a reliable phylogeny as the basis for classification of pestiviruses, a molecular dataset of 56 pestiviruses and 2089 characters, comprising the 5'UTR, complete N-pro and E2 gene regions was analysed by Maximum likelihood and Bayesian approach. An identical, robust tree topology was inferred, where seven well-supported monophyletic clades and two highly divergent lineages were identified. Dating most recent common ancestor was estimated for major pestivirus lineages and their evolutionary histories were revealed. Accordingly, a new proposal is presented for the classification of pestiviruses into nine species: BVDV-1, BVDV-2, BVDV-3 (atypical bovine pestiviruses), Pestivirus of giraffe, CSFV, BDV, Tunisian sheep Virus (TSV; previously termed "Tunisian isolates"), Antelope and Bungowannah. (c) 2008 Elsevier Inc. All rights reserved.