Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
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DOI：
10.1111/j.1399-0039.2005.00478.x
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发表时间：
2005-10-01
期刊：
影响因子：
--
通讯作者：
Wang, SS
中科院分区：
文献类型：
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作者：
Carreon, JD;Martin, MP;Wang, SS
人类白细胞抗原（HLA）变异可能会影响对人乳头瘤病毒感染的免疫反应以及随后的宫颈肿瘤风险。我们在美国和哥斯达黎加进行的三项宫颈肿瘤研究中，调查了宫颈癌/高级别病变女性 (n = 365) 和细胞学正常人群对照 (n = 681) 中 HLA-A-B 和 HLA-A-B-DR 单倍型之间的频率和关系。观察到单倍型频率的显着差异； HLA-A*01-B*08 单倍型出现在 > 5% 的美国白种人中，但在 < 1% 的哥斯达黎加人中出现。哥斯达黎加最常见的 HLA-A*24-B*40-DR*04 单倍型 (5%) 在不到 1% 的美国白种人中被发现。没有 HLA 单倍型与宫颈肿瘤显着相关，这表明迄今为止报告的个体等位基因关联（例如 HLA-DR*13）不太可能由潜在单倍型解释。
Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in > 5% of US Caucasians but in < 1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in < 1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.