SYNTHESIS OF ANGULARLY SUBSTITUTED OCTA- AND DECAHYDROQUINOLINES
SYNTHESIS OF ANGULARLY SUBSTITUTED OCTA- AND DECAHYDROQUINOLINES
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DOI：
10.1021/jo01063a031
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发表时间：
1961-01-01
影响因子：
3.6
通讯作者：
OSTERCAMP, DL
中科院分区：
文献类型：
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作者：
KOELSCH, CF;OSTERCAMP, DL
4a-苯基-Δ 8-八氢-2，7-喹啉二酮（Ⅰ）及其V-甲基衍生物用氢和钯、氢和镍以及用氢化铝锂还原。最终还原产物为4 α-苯基十氢喹啉或其V-甲基衍生物，但选择合适的还原剂可得到产率较高的各种中间体。
4a-Phenyl-A8-octahydro-2, 7-quinolinedione (I) and its V-methyl derivative have been reduced with hydrogen and palla-dium, hydrogen and nickel, and with lithium aluminum hydride. The ultimate reduction product is 4a-phenyldecahydroquinoline or its V-methyl derivative, but selection of an appropriate reducing agentenables one to obtain various inter-mediates in good yield.