An immunohistochemical study of the expression of adhesion molecules in gallbladder lesions
An immunohistochemical study of the expression of adhesion molecules in gallbladder lesions
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DOI：
10.1177/002215540405200504
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发表时间：
2004-05-01
影响因子：
3.2
通讯作者：
Kim, SH
中科院分区：
文献类型：
--
作者：
Choi, YL;Xuan, YH;Kim, SH
我们采用免疫组化方法研究了10种粘附分子（α -catenin、β -catenin、γ -catenin、CD44、CD44v6、ICAM-1、CD56、CEA、E-cadherin和CD99）在46例胆囊癌、14例腺瘤、15例低级别发育不良、9例肠化生和20例正常胆囊上皮组织中的表达。粘附分子在胆囊癌和腺瘤中的表达发生改变。在胆囊癌中，ICAM-1、CEA和CD44v6的表达增加，α / β / γ -catenin和CD99的表达减少。在腺瘤中，CD44v6和CD56的异常表达，以及α / β / γ -和e -钙粘蛋白的表达减少被注意到。α / β / γ -连环蛋白在轻度发育不良中表达减少，而在化生中这些粘附分子的表达没有变化。ICAM-1、CD99、E-cadherin、CD56的表达与临床分期相关。此外，ICAM-1和E-cadherin的表达与淋巴结转移之间存在相关性(p
We investigated the expression of 10 adhesion molecules (alpha-catenin, beta-catenin, gamma-catenin, CD44, CD44v6, ICAM-1, CD56, CEA, E-cadherin, and CD99) in 46 gallbladder carcinomas, 14 adenomas, 15 low-grade dysplasias, nine intestinal metaplasias, and 20 samples of normal gallbladder epithelium by immunohistochemistry. The expression of adhesion molecules was altered in gallbladder carcinomas and adenomas. In gallbladder carcinomas, increased expression of ICAM-1, CEA, and CD44v6 was observed, together with decreased expression of alpha/beta/gamma-catenin and CD99. In adenomas, aberrant expression of CD44v6 and CD56, as well as reduced expression of alpha/beta/gamma- and E-cadherins, was noted. Expression of alpha/beta/gamma-catenin was reduced in low-grade dysplasia, whereas there was no change in the expression of these adhesion molecules in metaplasia. Expression of ICAM-1, CD99, E-cadherin, and CD56 was correlated with clinical stage. In addition a correlation was noted between expression of ICAM-1 and E-cadherin and lymph node metastasis (p