Dioxin Concentrations in Breast Milk of Vietnamese Nursing Mothers: A Survey Four Decades after the Herbicide Spraying
Dioxin Concentrations in Breast Milk of Vietnamese Nursing Mothers: A Survey Four Decades after the Herbicide Spraying
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DOI：
10.1021/es201666d
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发表时间：
2011-08-01
影响因子：
11.4
通讯作者：
Nishijo, Hisao
中科院分区：
文献类型：
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作者：
Pham The Tai;Nishijo, Muneko;Nishijo, Hisao
在1961年至1971年的一次行动中，美国武装部队在南越喷洒了大量除草剂。这些除草剂含有2，3，7，8-四氯二苯并对二恶英（2，3，7，8-tetraCDD），这是二恶英毒性最大的同系物。在停止喷洒除草剂几十年后，喷洒地区环境和人体中的二恶英浓度仍然很高。从520名居住在热点地区以及喷洒和未喷洒地区的哺乳母亲那里收集了母乳样本，以量化二恶英的水平。生活在热点地区、喷洒区和未喷洒区的母亲母乳中的2，3，7，8-取代的多氯二苯并对二恶英/多氯二苯并呋喃的总毒性当量分别为14.10皮克/克脂质、10.89皮克/克脂质和4.09皮克/克脂质（对经产妇而言），11.48皮克/克脂质、7.56皮克/克脂质和2.84皮克/克脂质（对经产妇而言）。三个区域之间的值存在显著差异。在热点地区，二恶英水平与母亲的居住地高度相关，调整后的年龄和产次。
In an operation by United States Armed Forces during 1961 to 1971, large quantities of herbicides were sprayed in South Vietnam. These herbicides contained 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tetraCDD), the most toxic congener of dioxins. Several decades after the herbicide spraying ceased, dioxin concentrations in the environment and human remained elevated in the sprayed areas. Breast milk samples from 520 nursing mothers residing in areas including the hot spots as well as the sprayed and unsprayed areas were collected to quantify the levels of dioxins. The total toxic equivalents of 2,3,7,8-substitued PCDDs/PCDFs in breast milk of mothers living in the hot spots, and the sprayed and unsprayed areas were 14.10 pg/g lipid, 10.89 pg/g lipid, and 4.09 pg/g lipid for primiparae and 11.48 pg/g lipid, 7.56 pg/g lipid, and 2.84 pg/g lipid for multiparae, respectively, with significant differences in the values among the three areas. In the hot spots, dioxin levels were highly correlated with die residency of mothers after adjustment for their age and parity.