Variations in the behaviors to novel objects among five inbred strains of mice
Variations in the behaviors to novel objects among five inbred strains of mice
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DOI：
10.1111/j.1601-183x.2005.00133.x
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Shin, HS
中科院分区：
文献类型：
--
作者：
Kim, D;Chae, S;Shin, HS
新奇刺激引起各种行为反应，如探索和回避，和上下文变量可能有助于行为输出。在这里，我们试图比较五个近交系小鼠（C57 BL/6 J，129/svJae，C3 H/HeJ，BALB/cJ和DBA/2 J）的行为反应，通过使用一种改进的新物体测试，其中一个小的轻重量立方体用纸包裹在一个没有被褥的笼子里的小鼠。C57 BL/6 J、129/svJae和C3 H/HeJ小鼠对这些物体的反应表现出轻微的探索行为，如接近、嗅闻或短暂接触。与此形成鲜明对比的是，BALB/cJ和DBA/2 J小鼠在其他行为模式中表现出高回避/低探索，在最初的主要探索行为之后，对物体表现出玩耍样的次级反应。具体来说，DBA/2 J小鼠会在笼子里移动物体，用嘴叼着它，而BALB/cJ小鼠会啃咬物体，最终剥去包装纸。当类似的物体被重复呈现时，这种行为就会减少。目前的研究结果表明，主动操作的新对象可能是一个相关的参数，用于测量新奇诱导的行为在小鼠中，并出现强烈的遗传因素的影响。
Novelty stimuli cause various behavioral responses, such as exploration and avoidance, and contextual variables may contribute to the behavioral outputs. Here, we tried to compare the behavioral responses to novel objects of five inbred strains of mice (C57BL/6J, 129/svJae, C3H/HeJ, BALB/cJ and DBA/2J) by using a modified novel object test where a small light-weight cube wrapped with paper was presented to mice in a home cage without beddings. In response to these objects, the C57BL/6J, 129/svJae and C3H/HeJ mice showed mild exploratory behaviors, such as approaching, sniffing or brief contact. In striking contrast, the BALB/cJ and DBA/2J mice, which have been known to show high avoidance/low exploration in other behavioral paradigms, exhibited play-like secondary reactions toward the objects after initial primary exploratory behaviors. Specifically, DBA/2J mice would move the object around in the cage, holding it with their mouths, and BALB/cJ mice would gnaw the object, eventually stripping off the wrapping paper. Such behaviors decreased when similar objects were presented repeatedly. The present results suggest that active manipulations of novel objects may be a relevant parameter for measuring novelty-induced behaviors in mice and appear to be strongly influenced by genetic factors.