EPIDEMIOLOGIC ASSESSMENT OF CHRONIC ATRIAL-FIBRILLATION AND RISK OF STROKE - FRAMINGHAM STUDY
EPIDEMIOLOGIC ASSESSMENT OF CHRONIC ATRIAL-FIBRILLATION AND RISK OF STROKE - FRAMINGHAM STUDY
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DOI：
10.1212/wnl.28.10.973
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发表时间：
1978-01-01
期刊：
影响因子：
9.9
通讯作者：
KANNEL, WB
中科院分区：
文献类型：
--
作者：
WOLF, PA;DAWBER, TR;KANNEL, WB
慢性心房颤动（AF）作为中风的前兆在美国马萨诸塞州弗雷明汉的24年随访中进行了评估。慢性房颤患者，伴或不伴风湿性心脏病（RHD），卒中风险大大增加，卒中可能是由栓塞引起的。无RHD的慢性房颤与卒中发生率增加5倍以上相关，而合并RHD的房颤增加17倍。随着房颤持续时间的增加，卒中发生率也随之增加，没有证据表明这是一个特别脆弱的时期。慢性特发性房颤是脑栓塞的重要前兆。对慢性房颤患者使用抗凝剂或抗心律失常药物的对照试验可能会证明在这一高度易感人群中是否可以预防中风。
Chronic atrial fibrillation (AF) as a precursor of stroke was assessed over 24 yr follow-up of the general population sample at Framingham, Massachusetts [USA]. Persons with chronic established AF, with or without rheumatic heart disease (RHD), are at greatly increased risk of stroke and the stroke is probably due to embolism. Chronic AF in the absence of RHD is associated with more than a 5-fold increase in stroke incidence, while AF with RHD has a 17-fold increase. Stroke occurrence increased as duration of AF increased, with no evidence of a particularly vulnerable period. Chronic idiopathic AF is an important precursor of cerebral embolism. Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.