Spatial expression of the genome: the signal hypothesis at forty.
Spatial expression of the genome: the signal hypothesis at forty.
复制标题
基因组的空间表达：四十岁时的信号假设。
DOI：
10.1038/nrm3105
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Matlin,KarlS
中科院分区：
文献类型：
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作者：
Matlin,KarlS
信号假说由Günter Blobel和大卫萨巴蒂尼在1971年提出，并由Blobel和他的同事在1975年至1980年期间详细阐述，通过引入局部信号的概念，从根本上扩展了我们对细胞的看法。细胞不再仅仅是具有划分的生化功能的形态实体;它们现在是创造和延续自身形式和身份的积极参与者，是线性遗传信息到三维的解码器。
The signal hypothesis, formulated by Günter Blobel and David Sabatini in 1971, and elaborated by Blobel and his colleagues between 1975 and 1980, fundamentally expanded our view of cells by introducing the concept of topogenic signals. Cells were no longer just morphological entities with compartmentalized biochemical functions; they were now active participants in the creation and perpetuation of their own form and identity, the decoders of linear genetic information into three dimensions.