A Discrete-Time Branching Process Model of Yeast Prion Curing Curves.
A Discrete-Time Branching Process Model of Yeast Prion Curing Curves.
复制标题
酵母朊病毒固化曲线的离散时间分支过程模型。
DOI：
10.1080/08898480.2013.748566
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发表时间：
2013
影响因子：
1.8
通讯作者：
Olofsson,Peter
中科院分区：
文献类型：
--
作者：
Sindi,SuzanneS;Olofsson,Peter
许多神经退行性疾病的感染性病原体被认为是在细胞间传播的普恩蛋白聚集体。最近在酵母上的研究支持这一假设，但也表明只有临界大小以下的聚集体才能有效传播。一个典型细胞中可传递的聚集体的总数是菌株感染力的关键决定因素。在一个含有Pron的酵母菌落的离散时间分枝过程模型中，Pron聚集体的大小按泊松过程增加，在细胞分裂过程中，只有低于阈值大小的聚集体才被传递。表达了在不断增长的酵母种群中具有聚集体的细胞总数。
The infectious agent of many neurodegenerative disorders is thought to be aggregates of prion protein, which are transmitted between cells. Recent work in yeast supports this hypothesis but also suggests that only aggregates below a critical size are transmitted efficiently. The total number of transmissible aggregates in a typical cell is a key determinant of strain infectivity.In a discrete-time branching process model of a yeast colony with prions, prion aggregates increase in size according to a Poisson process and only aggregates below a threshold size are transmitted during cell division. The total number of cells with aggregates in a growing population of yeast is expressed.