Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.
Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.
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DOI：
10.1111/dom.12275
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Bray GA
中科院分区：
文献类型：
--
作者：
Shin JH;Gadde KM;Østbye T;Bray GA
We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomized controlled trial in which they received daily placebo, zonisamide 200 mg, or zonisamide 400 mg, in addition to lifestyle counseling. Of the originally randomized 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n=53), zonisamide 200 mg (n=49), and zonisamide 400 mg groups (n=52) were 0.5 kg (95% CI, −0.8 to 1.8; 0.7%), 1.5 kg (0.2 to 2.8; 1.6%; p=0.26 vs placebo) and 2.4 kg (1.1 to 3.7; 2.6%; p=0.04 vs placebo), respectively. Our results suggest that although zonisamide 400 mg daily for 12-months resulted in greater weight loss than with placebo, weight regain after discontinuation of interventions was greater in the zonisamide 400 mg group than placebo group.
DOI：
10.1002/j.1550-8528.1999.tb00701.x
发表时间：
1999-03-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Bray, GA;Blackburn, GL;Seaton, TB
通讯作者：
Seaton, TB
影响因子：
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作者：
Gadde, Kishore M.;Kopping, Mariko F.;Bray, George A.
通讯作者：
Bray, George A.
影响因子：
120.7
作者：
Gadde, KM;Franciscy, DM;Krishnan, KRR
通讯作者：
Krishnan, KRR