Bacterial Diversity and Chemical Ecology of Natural Product-Producing Bacteria from Great Salt Lake Sediment.
Bacterial Diversity and Chemical Ecology of Natural Product-Producing Bacteria from Great Salt Lake Sediment.
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大盐湖沉积物中天然产物生产细菌的细菌多样性和化学生态学。
DOI：
10.1101/2023.11.07.565188
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Winter,JaclynM
中科院分区：
文献类型：
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作者：
BringHorvath,ElijahR;Brazelton,WilliamJ;Kim,MinCheol;Cullum,Reiko;Mulvey,MatthewA;Fenical,William;Winter,JaclynM
大盐湖（GSL）位于犹他州盐湖城西北部，是美国最大的终端湖。虽然海水的平均盐度约为 3.3%，但 GSL 的盐度范围在 5% 至 28% 之间。除了高盐度环境外，GSL 还含有有毒浓度的重金属，如砷、汞和铅。 GSL 的极端环境使其成为一个有趣的研究课题，不仅因为其独特的微生物组，还因为它拥有生产新型天然产物的细菌的潜力，这些细菌可以作为发现生物活性化合物的资源。尽管已经开展了对 GSL 中发现的细菌的调查和编目工作，但该湖的微生物群在很大程度上尚未被探索，并且几乎没有开展任何工作来表征 GSL 微生物的天然产品潜力。在这里，我们研究了 GSL 内两个重要区域的细菌多样性，描述了从 GSL 沉积物中分离出的放线菌的首次基因组特征，包括鉴定了两个新的放线菌物种，并首次调查了 GSL 细菌的天然产物潜力。
Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the USA. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5% and 28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product–producing bacteria, which could be used as resources for the discovery of biologically active compounds. Though work has been done to survey and catalog bacteria found in GSL, the Lake’s microbiome is largely unexplored, and little to no work has been done to characterize the natural product potential of GSL microbes. Here, we investigate the bacterial diversity of two important regions within GSL, describe the first genomic characterization of Actinomycetota isolated from GSL sediment, including the identification of two new Actinomycetota species, and provide the first survey of the natural product potential of GSL bacteria.