RELATIVE CONTRIBUTIONS OF AGING AND ESTROGEN DEFICIENCY TO POSTMENOPAUSAL BONE LOSS
RELATIVE CONTRIBUTIONS OF AGING AND ESTROGEN DEFICIENCY TO POSTMENOPAUSAL BONE LOSS
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DOI：
10.1056/nejm198411153112002
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发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
RIGGS, BL
中科院分区：
文献类型：
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作者：
RICHELSON, LS;WAHNER, HW;RIGGS, BL
关于衰老或雌激素缺乏是否是绝经后骨质流失更重要的决定因素的争论仍在继续。比较了年轻时接受过卵巢切除术的女性 (14)、14 名正常围绝经期女性和 14 名正常绝经后女性（平均年龄分别为 54、52 和 73 岁；雌激素缺乏的平均持续时间分别为 22、0.3 和 22 岁）。通过单光子和双光子吸收测定法评估骨矿物质密度。与围绝经期组相比，其他2组的桡骨正中、股骨颈、股骨粗隆间区和腰椎骨密度显着降低（绝经后组分别为-15%、-25%、-16%和-23%）。由于卵巢切除组（绝经状态与围绝经期组不同，但年龄不同）的骨质流失几乎与绝经后组（两者特征不同）一样大，雌激素缺乏而不是衰老，可能是自然绝经后第一个二十年发生骨质流失的主要原因。 [讨论了绝经后妇女骨质疏松症和相关骨折的发展。]
Debate continues on whether aging or estrogen deficiency is the more important determinant of postmenopausal bone loss. Women (14) who had undergone oophorectomy during young adulthood, 14 normal perimenopausal women and 14 nomral postmenopausal women (mean ages, 54, 52 and 73 yr, respectively; mean duration of estrogen deficiency, 22, 0.3 and 22 yr, respectively), were compared. Bone mineral density was assessed by single-photon and dual-photon absorptiometry. As compared with the perimenopausal group, the other 2 groups had significantly lower bone mineral density at the midradius, femoral neck, femoral intertrochanteric area and lumbar spine (-15%, -25%, -16% and -23%, respectively, in the postmenopausal group). Because bone loss in the oophorectomized group (differing from the perimenopausal group in menopausal status but not in age) was almost as great as in the postmenopausal group (differing in both characteristics), estrogen deficiency and not aging, may be the predominant cause of bone loss occurring during the 1st two decades after natural menopause. [The development of osteoporosis and associated bone fractures in postmenopausal women was discussed.].