Rat intestinal lymph osmolarity during glucose and oleic acid absorption.
Rat intestinal lymph osmolarity during glucose and oleic acid absorption.
复制标题
葡萄糖和油酸吸收过程中大鼠肠道淋巴渗透压。
DOI：
10.1152/ajpgi.1989.257.3.g438
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Unthank,JL
中科院分区：
文献类型：
--
作者：
Bohlen,HG;Unthank,JL
本研究的两个主要目的是确定1）肠绒毛对葡萄糖和油酸的吸收如何影响淋巴液离开绒毛基底时的渗透组成，以及2）当淋巴液穿过肠壁时，淋巴液渗透压是否发生任何变化。在所有研究中均使用大鼠空肠，在对照状态和管腔暴露于35-550 mg%葡萄糖溶液（等渗盐水）和5和20 mM油酸牛磺胆酸盐溶液期间，以0.5-1 nl/min的速度从个体空肠收集淋巴液。在剧烈运动期间从绒毛基部收集的淋巴液在静止时的渗透压为403 +/- 15 mosM，并且除了暴露于550 mg%葡萄糖期间渗透压增加超过100 mosM之外，仅增加30-50 mosM。在可比条件下，静息时粘膜下淋巴渗透压为302 +/- 3.5 mosM，在暴露于所有供试溶液期间增加至330-350 mosM。当肠蠕动几乎停止时，所有供试溶液的粘膜下淋巴渗透压均为等渗。这些观察结果表明，葡萄糖和油酸的吸收增加了淋巴液的渗透压，使绒毛只有30-50 mosM，除非存在550 mg%的葡萄糖浓度。此外，当肠运动辅助淋巴推进时，吸收过程中绒毛淋巴流量的增加提高了粘膜下淋巴的渗透压。通过微静脉血液和淋巴液流将物质从绒毛移动到粘膜下层，为绒毛组织影响粘膜下层间质环境的组成提供了机会。
The two major purposes of this study were to determine 1) how glucose and oleic acid absorption by the intestinal villi influenced the osmotic composition of lymph as it exited the villus base and 2) what if any changes in lymph osmolarity occurred as the lymph traversed through the bowel wall. The rat jejunum was used in all studies and lymph was collected from individual lymphatics at 0.5-1 nl/min during control states and luminal exposure to 35-550 mg% glucose solutions (isotonic in saline) and 5 and 20 mM oleic acidtaurocholate solutions. Lymph collected from the base of villi during vigorous motility had an osmolarity of 403 +/- 15 mosM at rest and was only increased 30-50 mosM more except during exposure to 550 mg% glucose, where osmolarity increased over 100 mosM. Under comparable conditions, the submucosal lymph osmolarity at rest was 302 +/- 3.5 mosM and increased to 330-350 mosM during exposure to all of the solutions tested. When intestinal motility was virtually stopped, the submucosal lymph osmolarity was isotonic for all solutions tested. These observations indicate that absorption of glucose and oleic acid increased the osmolarity of lymph, leaving the villus only 30-50 mosM unless a glucose concentration of 550 mg% was present. Furthermore, the increased flow of villus lymph during absorption raised the osmolarity of the submucosal lymph when bowel motility assisted the lymph propulsion. This movement of materials from the villus to the submucosa by venular blood and lymph flow provides an opportunity for the villus tissue to influence the composition of the submucosal interstitial environment.
儿童和青少年的吸烟和烟草使用行为：Bogalusa 心脏研究☆
DOI：
--
发表时间：
1980
期刊：
影响因子：
--
作者：
S. Hunter;L. Webber;G. Berenson
通讯作者：
G. Berenson
新墨西哥州美洲印第安人和西班牙裔的呼吸道疾病死亡率。
影响因子：
12.7
作者：
J. Samet;C. Key;D. Kutvirt;C. Wiggins
通讯作者：
C. Wiggins