Parathyroid and thyroid hormones in the development of immobilization osteoporosis.
Parathyroid and thyroid hormones in the development of immobilization osteoporosis.
复制标题
甲状旁腺和甲状腺激素在固定性骨质疏松症的发展中。
作者：
James M. Burkhart;Jenifer Jowsey
该实验旨在确定固定时观察到的骨质疏松症是否是局部因素的结果，或者是由于循环激素的作用而发生的，这些激素在固定部位更有效。考虑的激素是来自甲状腺和甲状旁腺的激素。将30只成年犬分为4组：完整组、甲状旁腺切除组、甲状腺切除组和甲状腺甲状旁腺切除组。右后肢固定在一个单一的髋关节spica石膏，这是更换每周一次。3 ~ 12周后，从每只动物的固定和非固定肢体中取出胫骨和1个跖骨，进行定量显微放射学研究;测量这2个骨的中段的孔隙度、骨形成和骨吸收。在选定的动物中测量动脉和静脉胫骨血液的pCO 2和pO 2以及pH。结果表明，3周后既有肿瘤学证据，又有显微放射学证据。
The experiment was designed to determine whether the osteoporosis observed with immobilization is the result of local factors or develops in response to circulating hormones, which are more effective in the immobilized part. The hormones considered were those from thethyroid and parathyroid glands. Thirty adult dogs were divided into 4 groups: intact, parathyroidectomized, thyroidectomized and thyroparathyroidectomized. The right hind limbs were immobilized in a single hip spica cast, which was replaced at weekly intervals. After 3 to 12 weeks, the tibia and 1 metatarsal were removed from the immobilized and nonimmobilized limbs of each animal, and quantitative microradiographic studies were carried out; the degree of porosity, bone formation and bone resorption were measured in the midshaft of these 2 bones. The pCO2 and pO2 and pH of arterial and venous tibial blood were measured in selected animals. The results showed that after 3 weeks there were both l'oentgenologic evidence and microradiographic evi...