Necroptosis, pyroptosis and apoptosis: an intricate game of cell death.
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death.
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DOI：
10.1038/s41423-020-00630-3
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发表时间：
2021-05
影响因子：
24.1
通讯作者：
Franklin BS
中科院分区：
文献类型：
--
作者：
Bertheloot D;Latz E;Franklin BS
细胞死亡是所有生物体的基本生理过程。它的作用从胚胎发育、器官维护和衰老到免疫反应和自身免疫的协调。近年来，我们对细胞死亡的机制及其对免疫和体内平衡的影响的理解大大增加。已经描述了被称为“程序性细胞死亡”的不同模式，并且已经确定了这些过程中的一些关键参与者。我们已经了解了更多关于微调共同参与者活动并最终塑造不同类型细胞死亡的复杂性。这些研究强调了不同细胞命运之间平衡的复杂机制。在这里，我们总结了最新发现的三种最好理解的细胞死亡方式，即凋亡，坏死性凋亡和焦亡，突出共同和独特的途径及其对周围细胞和整个生物体的影响。
Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity. In recent years, our understanding of the mechanisms orchestrating cellular death and its consequences on immunity and homeostasis has increased substantially. Different modalities of what has become known as ‘programmed cell death’ have been described, and some key players in these processes have been identified. We have learned more about the intricacies that fine tune the activity of common players and ultimately shape the different types of cell death. These studies have highlighted the complex mechanisms tipping the balance between different cell fates. Here, we summarize the latest discoveries in the three most well understood modalities of cell death, namely, apoptosis, necroptosis, and pyroptosis, highlighting common and unique pathways and their effect on the surrounding cells and the organism as a whole.
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DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
30.5
作者：
Baroja-Mazo, Alberto;Martin-Sanchez, Fatima;Pelegrin, Pablo
通讯作者：
Pelegrin, Pablo
影响因子：
56.9
作者：
Bauernfried, Stefan;Scherr, Matthias J.;Hornung, Veit
通讯作者：
Hornung, Veit
影响因子：
64.8
作者：
Brummelkamp, TR;Nijman, SMB;Bernards, R
通讯作者：
Bernards, R
DOI：
10.4049/jimmunol.1701492
发表时间：
2018-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brault M;Olsen TM;Martinez J;Stetson DB;Oberst A
通讯作者：
Oberst A