Serum selenium and serum lipids in US adults.
Serum selenium and serum lipids in US adults.
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DOI：
10.1093/ajcn/88.2.416
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发表时间：
2008-08
期刊：
影响因子：
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通讯作者：
Guallar E
中科院分区：
文献类型：
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作者：
Bleys J;Navas-Acien A;Stranges S;Menke A;Miller ER 3rd;Guallar E
硒是一种必需的微量营养素，因其抗氧化性能而备受关注。此外，硒可能会影响几个心脏代谢危险因素，如葡萄糖动态平衡和血脂浓度。然而，在美国等富硒人群中，硒摄入量对血脂谱的影响在很大程度上是未知的。我们在一个具有代表性的美国成年人样本中研究了血清硒浓度与血脂的关系。本研究对参加第三次全国健康与营养调查的5,452名20岁≥男女进行了横断面分析。用原子吸收光谱法测定血清硒含量。总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白B和载脂蛋白A-I的多变量调整差分别为16.6 mg/dL(95%CI：11.6，21.4 mg/dL)，10.9 mg/dL(95%CI：6.4，15.4 mg/dL)，3.2 mg/dL(95%CI：1.6，5.0 mg/dL)，8.9 mg/dL(95%CI：5.6，5.0 mg/dL)，12.2 mg/dL)和6.9 mg/dL(95%CI分别为1.7、12.1 mg/dL)。血清硒含量最高四分位数的受试者三酰甘油浓度比最低四分位数的受试者高10%(三酰甘油浓度比：1.10；95%可信区间：1.05，1.17)。低密度脂蛋白胆固醇/高密度脂蛋白胆固醇和载脂蛋白B/载脂蛋白A-I与最高和最低硒四分位的比值分别为0.11(95%可信区间：−0.02，0.25)和0.03(95%可信区间：0.00，0.06)。在硒充足的美国成年人中，血清硒升高与血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、三酰甘油、载脂蛋白B和载脂蛋白A-I浓度升高有关。需要进行实验研究来确定因果关系以及这些关联背后的潜在机制。
Selenium, an essential micronutrient, has received considerable attention for its antioxidant properties. In addition, selenium may affect several cardiometabolic risk factors, such as glucose homeostasis and lipid concentrations. However, the effects of selenium intake on the lipid profile in selenium-replete populations, such as the United States, are largely unknown. We examined the relation of serum selenium concentrations with serum lipids in a representative sample of US adults. This was a cross-sectional analysis of 5452 men and women aged ≥ 20 y participating in the third National Health and Nutrition Examination survey. Serum selenium was measured by atomic absorption spectrometry. The multivariable adjusted differences in total cholesterol, LDL cholesterol, HDL cholesterol, apolipoprotein B (apo B), and apolipoprotein A-I (apo A-I) comparing the highest with the lowest quartile of serum selenium were 16.6 mg/dL (95% CI: 11.6, 21.4 mg/dL), 10.9 mg/dL (95% CI: 6.4, 15.4 mg/dL), 3.2 mg/dL (95% CI: 1.6, 5.0 mg/dL), 8.9 mg/dL (95% CI: 5.6, 12.2 mg/dL), and 6.9 mg/dL (95% CI: 1.7, 12.1 mg/dL), respectively. Participants in the highest quartile of serum selenium had 10% higher concentrations of triacylglycerols than did participants in the lowest quartile (ratio of triacylglycerol concentrations: 1.10; 95% CI: 1.05, 1.17). The difference in the ratios of LDL cholesterol to HDL cholesterol and apo B to apo A-I that compared the highest with the lowest selenium quartiles were 0.11 (95% CI: −0.02, 0.25) and 0.03 (95% CI: 0.00, 0.06), respectively. Elevated serum selenium was associated with elevated serum concentrations of total cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols, apo B, and apo A-I among US adults, a selenium-replete population. Experimental studies are needed to determine cause and effect relations and the potential mechanisms underlying these associations.