Antimicrobial agents in the treatment of bacterial meningitis
Antimicrobial agents in the treatment of bacterial meningitis
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DOI：
10.1016/j.idc.2004.04.005
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发表时间：
2004-09-01
影响因子：
4.4
通讯作者：
Tunkel, AR
中科院分区：
文献类型：
--
作者：
Sinner, SW;Tunkel, AR
近年来，抗菌药物在急性细菌性脑膜炎治疗中的应用发生了重大变化。有大量的体外和动物模型数据支持使用特定的抗菌剂治疗细菌性脑膜炎，尽管并不是所有的方案都已在临床试验中进行了评估。最近的研究集中在扩大潜在的抗菌药配方，以在这个抗菌素耐药性不断增加的时代有效地管理细菌性脑膜炎患者。尽管取得了这些进展，但急性细菌性脑膜炎的发病率和死亡率仍然高得令人无法接受。尽管有人担心地塞米松可能会减少某些抗菌剂在脑脊液中的渗透率，但地塞米松的使用已被证明可以改善细菌性脑膜炎患者的发病率和死亡率。
The use of antimicrobial agents in the treatment of acute bacterial meningitis has undergone significant changes in recent years. There is a wealth of in vitro and animal model data that support the use of the specific antimicrobial agents in the treatment of bacterial meningitis, although not all regimens have been evaluated in clinical trials. Recent investigations have focused on expanding the potential antimicrobial formulary to manage patients with bacterial meningitis effectively in this era of increasing antimicrobial resistance. Despite these advances, the morbidity and mortality of acute bacterial meningitis remain unacceptably high. The use of adjunctive dexamethasone has been shown to improve morbidity and mortality in patients with bacterial meningitis, although concerns have been raised that dexamethasone may reduce penetration of certain antimicrobial agents into cerebrospinal fluid.