Segmentation and volumetric analysis of the caudate nucleus in Alzheimer's disease
Segmentation and volumetric analysis of the caudate nucleus in Alzheimer's disease
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DOI：
10.1016/j.ejrad.2013.03.012
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发表时间：
2013-09-01
影响因子：
3.3
通讯作者：
Jayasree, Ramapurath S.
中科院分区：
文献类型：
--
作者：
Jiji, Sudevan;Smitha, Karavallil Achuthan;Jayasree, Ramapurath S.
目的：尾状核体积定量分析对阿尔茨海默病(AD)的早期诊断和预后判断有重要意义。本研究的目的是从MR图像中估计节段性尾状核的体积，并将节段性体积的变化与总脑体积相关联。我们还试图评估一组阿尔茨海默病患者的脑白质(WM)、灰质(GM)和脑脊液(CSF)的年龄相关性萎缩与尾状核萎缩的关系。方法：选择15例AD患者、15例正常志愿者和15例正常诊断的患者的3D快速低角度拍摄(3D Flash)脑MR图像。分别使用统计参数图和半自动工具对脑组织和尾状核进行分割，并估计体积。节段性尾状核体积与脑体积呈正相关。结果：与正常志愿者相比，AD患者的尾状核体积明显缩小。统计学分析还显示AD患者GM和CSF的体积有显著差异。在脑外观正常的患者中，33%的患者尾状核体积有明显变化。我们推测，这些变化可以被认为是早期AD的迹象。结论：脑结构体积分析方法是早期诊断阿尔茨海默病等神经系统疾病的简单有效的方法。我们用观察到的一组患者尾状核体积的变化来说明这一点。对更多受试者的详细研究将有助于将这些结果关联起来，以用于AD的早期诊断。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: A quantitative volumetric analysis of caudate nucleus can provide valuable information in early diagnosis and prognosis of patients with Alzheimer's diseases (AD). Purpose of the study is to estimate the volume of segmented caudate nucleus from MR images and to correlate the variation in the segmented volume with respect to the total brain volume. We have also tried to evaluate the caudate nucleus atrophy with the age related atrophy of white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) in a group of Alzheimer's disease patients.Methods: 3D fast low angle shot (3D FLASH) brain MR images of 15 AD patients, 15 normal volunteers and 15 patients who had normally diagnosed MR images were included in the study. Brain tissue and caudate nuclei were segmented using the statistical parametric mapping package and a semi-automatic tool, respectively and the volumes were estimated. Volume of segmented caudate nucleus is correlated with respect to the total brain volume. Further, the caudate nucleus atrophy is estimated with the age related atrophy of WM, GM and CSF in a group of AD patients.Results: Significant reduction in the caudate volume of AD patients was observed compared to that of the normal volunteers. Statistical analysis also showed significant variation in the volume of GM and CSF of AD patients. Among the patients who had normal appearing brain, 33% showed significant changes in the caudate volume. We hypothesize that these changes can be considered as an indication of early AD.Conclusion: The method of volumetric analysis of brain structures is simple and effective way of early diagnosis of neurological disorders like Alzheimer's disease. We have illustrated this with the observed changes in the volume of caudate nucleus in a group of patients. A detailed study with more subjects will be useful in correlating these results for early diagnosis of AD. (C) 2013 Elsevier Ireland Ltd. All rights reserved.