Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry
Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry
复制标题
DOI：
10.1098/rsif.2008.0335
复制
发表时间：
2009-06
影响因子：
3.9
通讯作者：
K. Ishihara;M. Takai
中科院分区：
文献类型：
--
作者：
K. Ishihara;M. Takai
本文综述了用于纳米生物器件的新型生物界面。生物相容性和非生物污染表面主要是基于细胞膜结构设计的，生物激励界面的制备和功能在生物系统和人工系统之间进行了评估和比较。具有磷脂极性基团的聚合物分子组装已被开发为界面的平台。在表面，蛋白质的吸附被有效地减少，随后的生物反应被抑制。通过这个平台，可以在温和的条件下引入与特定分子具有高亲和力的生物分子。即使在固定化后，生物分子的活性也保持不变。这种受生物启发的界面适用于构建生物纳米器件，即用于捕获目标分子和细胞的微流控芯片和纳米颗粒。该接口功能良好，具有很高的生物识别效率。这种以生物为灵感的界面是一个很有前途的通用平台，它集成了各种科学领域，并具有有用的应用。
This review paper describes novel biointerfaces for nanobiodevices. Biocompatible and non-biofouling surfaces are designed largely based on cell membrane structure, and the preparation and functioning of the bioinspired interface are evaluated and compared between living and artificial systems. A molecular assembly of polymers with a phospholipid polar group has been developed as the platform of the interface. At the surface, protein adsorption is effectively reduced and the subsequent bioreactions are suppressed. Through this platform, biomolecules with a high affinity to the specific molecules are introduced under mild conditions. The activity of the biomolecules is retained even after immobilization. This bioinspired interface is adapted to construct bionanodevices, that is, microfluidic chips and nanoparticles for capturing target molecules and cells. The interface functions well and has a very high efficiency for biorecognition. This bioinspired interface is a promising universal platform that integrates various fields of science and has useful applications.