Changing gender prevalence of stone disease
Changing gender prevalence of stone disease
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DOI：
10.1016/j.juro.2006.10.069
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发表时间：
2007-03-01
影响因子：
6.6
通讯作者：
Preminger, Glenn M.
中科院分区：
文献类型：
--
作者：
Scales, Charles D., Jr.;Curtis, Lesley H.;Preminger, Glenn M.
目的：最近的研究表明，肾结石形成的发病率一直在增加，男性占主导地位的肾结石正在减少，这可能是由于饮食和生活方式的变化。我们研究了泌尿系结石病住院患者出院时性别患病率的变化。材料和方法：全国住院患者样本用于分析。出院时国际疾病分类第9版临床修正主要诊断为592.0（肾结石）或592.1结果：1997年至2002年因结石病排出的尿量估计为± SE 1，013，621 ± 19，310例。在研究期间，肾结石的排出量增加了18.9%（p < 0.001），而输尿管结石的排出量保持相对稳定。调整人群变化后，肾结石的出院率增加了14.2%（p = 0.002）。在女性中，肾结石的排出量增加了21.0%，输尿管结石的排出量增加了19.2%（均p < 0.001）。调整人口变化后，女性肾结石和输尿管结石排放量分别增加了22.0%（p = 0.001）和14.5%（p = 0.005），结论：在这个具有全国代表性的样本中，人口调整率的女性结石病排放量显着增加，从1997年至2002年。这一变化代表了接受治疗的结石病的性别患病率从1.7：1变为1.3：1。它可能反映了结石病的性别基础患病率的变化。我们推测，肾结石的发病率增加可能是由于生活方式相关的危险因素，如肥胖。
Purpose: Recent studies suggest that the incidence of renal stone formation has been increasing and the male predominance of nephrolithiasis is decreasing, which may be due to changes in diet and lifestyle. We examined changes in the prevalence by gender of inpatient hospital discharges for urinary stone disease.Materials and Methods: The Nationwide Inpatient Sample was used for analysis. Discharges with an International Classification of Diseases, 9th revision, Clinical Modification principal diagnosis of 592.0 (calculus of kidney) or 592.1 (calculus of ureter) from 1997 to 2002 were included in the investigation.Results: An estimated mean +/- SE 1,013,621 +/- 19,310 discharges for stone disease occurred from 1997 to 2002. Discharges for renal calculus increased by 18.9% during the study period (p < 0.001), while discharges for ureteral calculus remained relatively constant. After adjusting for population changes discharges for renal calculi increased by 14.2% (p = 0.002). In females discharges for renal calculi increased by 21.0% and discharges for ureteral calculi increased by 19.2% (each p < 0.001). After adjusting for population changes renal calculus and ureteral calculus discharges in females increased by 22.0% (p = 0.001) and 14.5% (p = 0.005), respectively.Conclusions: In this nationally representative sample the population adjusted rate of discharges for stone disease in females dramatically increased from 1997 to 2002. This alteration represents a change in the prevalence by gender of treated stone disease from a 1.7:1 to 1.3:1 male-to-female ratio. It may reflect variations in the underlying prevalence by gender of stone disease. We speculate that the increasing incidence of nephrolithiasis might be due to lifestyle associated risk factors, such as obesity.