Gene induction following wounding of wild‐type versus macrophage‐deficient Drosophila embryos
Gene induction following wounding of wild‐type versus macrophage‐deficient Drosophila embryos
复制标题
野生型果蝇胚胎与巨噬细胞缺陷型果蝇胚胎受伤后的基因诱导
作者：
B. Stramer;M. Winfield;T. Shaw;T. Millard;S. Woolner;Paul Martin
By using a microarray screen to compare gene responses after sterile laser wounding of wild‐type and ‘macrophageless’ serpent mutant Drosophila embryos, we show the wound‐induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation‐associated gene, growth arrest and DNA damage‐inducible gene 45 (GADD45), is upregulated in both Drosophila and murine repair models. Comparison of unwounded wild‐type and serpent mutant embryos also shows a portfolio of ‘macrophage‐specific’ genes, which suggest analogous functions with vertebrate inflammatory cells. Besides identifying the various classes of wound‐ and macrophage‐related genes, our data indicate that sterile injury per se, in the absence of pathogens, triggers induction of a ‘pathogen response’, which might prime the organism for what is likely to be an increased risk of infection.
影响因子：
11.8
作者：
Agaisse, H;Petersen, UM;Perrimon, N
通讯作者：
Perrimon, N