Distinct component profiles and high risk among African Americans with metabolic syndrome - The Jackson Heart Study
Distinct component profiles and high risk among African Americans with metabolic syndrome - The Jackson Heart Study
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DOI：
10.2337/dc07-1810
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发表时间：
2008-06-01
期刊：
影响因子：
16.2
通讯作者：
Sung, Jung Hye
中科院分区：
文献类型：
--
作者：
Taylor, Herman;Liu, Jiankang;Sung, Jung Hye
目的-糖尿病和心血管疾病(CVD)的持续流行严重威胁着非裔美国人的健康。然而，代谢综合征在非裔美国人中的作用还没有得到广泛的研究。这项研究在杰克逊心脏研究(JHS)队列中检查了代谢综合征的患病率，并评估了它与心血管疾病的横断面关系。研究设计和方法--2000-2004年间招募的5,302名年龄为21岁的受试者被纳入本研究。对合并和不合并代谢综合征患者的冠心病(CHD)和脑血管疾病(CBD)进行Logistic回归分析，估计调整后的优势比(OR)。结果：在35-84岁的人群中，女性代谢综合征患病率为43.3%，男性为32.7%。高血压(70.4%)、腹型肥胖(64.6%)和低高密度脂蛋白胆固醇(37.2%)在代谢综合征患者中非常普遍。心血管疾病、冠心病和CBD的患病率分别为12.8%、8.7%和5.8%。在对年龄和性别进行调整后，与无心血管疾病、冠心病或胆总管疾病的患者相比，代谢综合征与心血管疾病(OR 1.7[95%CI 1.4-2.1])、冠心病(1.7[1.4-2.2])和胆总管疾病(1.7[1.3-2.3])的年龄和性别调整的OR值增加相关。结论代谢综合征在JHS人群中的患病率是全球人群队列中最高的报告之一，并与心血管疾病、CHD和CBD的OR值增加显著相关。腹型肥胖、血压升高和低高密度脂蛋白胆固醇(没有甘油三酯升高)是令人惊讶的突出问题。在这个庞大的非裔美国人队列中，低高密度脂蛋白的高流行率是导致非裔美国人代谢综合征的主要因素。
OBJECTIVE - Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort.RESEARCH DESIGN AND METHODS - A total of 5,302 participants aged >= 21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded.RESULTS - Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4-2.1]), CHD (1.7 [1.4-2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD.CONCLUSION - metabolic syndrome prevalence in the JHS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.