Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride.
Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride.
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DOI：
10.1039/d1cc00769f
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发表时间：
2021-05
影响因子：
4.9
通讯作者：
Yiyuan Zhang;Wan-Yi Chen;Tingting Tan;Yuang Gu;Shuning Zhang;Jie Li;Yan Wang;Wei Hou;
中科院分区：
文献类型：
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作者：
Yiyuan Zhang;Wan-Yi Chen;Tingting Tan;Yuang Gu;Shuning Zhang;Jie Li;Yan Wang;Wei Hou;
我们报道了一种通用的钯催化一锅法从硫酰氟介导的苯酚合成磷酸盐、磷酸盐和磷化氢氧化物的过程。它具有条件温和、底物范围广、高功能性耐受性和对水不敏感的特点。这一方法的实用性已经在克级合成、点击化学构件的顺序合成、药物和天然产物的后期修饰以及DNA编码库(DEL)中的氧化膦的DNA合成中得到了很好的证明。
We report a general palladium-catalyzed one-pot procedure for the synthesis of phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. It features mild conditions, broad substrate scope, high functionality tolerance and water insensitivity. The utility of this procedure has been well demonstrated by gram-scale synthesis, sequential synthesis of click chemistry building blocks, late-stage decoration of drugs and natural products and on-DNA synthesis of phosphine oxide for a DNA-encoded library (DEL).