Gender specific effect of neonatal handling on stress reactivity of adolescent rats.
Gender specific effect of neonatal handling on stress reactivity of adolescent rats.
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新生儿处理对青少年大鼠应激反应的性别特异性影响。
DOI：
10.1046/j.1365-2826.2003.01010.x
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发表时间：
2003
影响因子：
3.2
通讯作者：
Leslie,FM
中科院分区：
文献类型：
--
作者：
Park,MK;Hoang,TA;Belluzzi,JD;Leslie,FM
大鼠幼仔的早期新生处理可降低成年雄性后代的下丘脑-垂体-肾上腺轴对应激的反应性。然而，关于女性是否有类似的影响，人们知之甚少。虽然，大多数新生儿处理的研究已经检查了成年后的影响，青春期是一个重要的发展阶段的压力反应。为了解决这些问题，在青春期急性束缚应激反应中，确定了新生儿处理对雄性和雌性大鼠内分泌应激反应和大脑活动的影响。与之前在成年男性中的发现一致，新生儿处理降低了青少年男性的束缚应激诱导的激素水平。然而，相比之下，我们发现处理女性血浆激素浓度升高。性别特异性处理对大脑活动的影响也很明显，通过c-fosmRNA表达测量，处理雌性动物的后扣带回皮质的应激诱导激活显著增加。早期新生儿处理的效果显着的性别差异提供的证据表明，这必须被认为是一个重要的变量，在随后的压力反应诱导早期操作。
Early neonatal handling of rat pups produces dampened hypothalamic‐pituitary‐adrenal axis reactivity to stress in adult male offspring. However, less is known about whether there is a similar effect for females. Although, most studies of neonatal handling have examined subsequent effects during adulthood, adolescence is an important developmental stage for stress responsivity. To address these issues, the effect of neonatal handling on the endocrine stress response and brain activity of male and female rats was determined in response to acute restraint stress during adolescence. Consistent with previous findings in adult males, neonatal handling reduced restraint stress‐induced hormone levels in adolescent males. However, in contrast, we found elevated plasma hormone concentrations in handled females. A gender‐specific handling effect on brain activity was also evident, with significantly increased stress‐induced activation of the posterior cingulate cortex of handled females, as measured by c‐fosmRNA expression. The striking gender difference in the effect of early neonatal handling provides evidence that this must be considered as an important variable in subsequent stress responsivity induced by early manipulations.