Development of a theoretical framework for analyzing cerebrospinal fluid dynamics.
Development of a theoretical framework for analyzing cerebrospinal fluid dynamics.
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DOI：
10.1186/1743-8454-6-12
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发表时间：
2009-09-22
影响因子：
--
通讯作者：
Wei, Timothy
中科院分区：
文献类型：
--
作者：
Cohen, Benjamin;Voorhees, Abram;Wei, Timothy
背景：迄今为止，脑积水研究人员承认在研究正常和脑积水颅内动力学时需要严格但实用的流体力学理解和方法。压力体积模型和电路模拟将压力引入体积守恒；但控制体积分析强制执行压力和体积的独立条件。以前，临床测量的利用仅限于了解流量、体积和压力波形的相对幅度和时间。定性方法没有明确的有意义的定量比较框架。方法：控制体积分析向读者介绍了这种应用于一般控制体积的基础流体力学技术的理论背景。这种方法能够直接整合临床医生获得的各种测量结果，以更好地阐明颅内动力学和疾病进展。结果：讨论了有意义的颅内控制体积的几个例子以及分析所需的特定测量集。结论：控制体积分析提供了一个框架来指导测量的类型和位置，也是一种在基本流体物理分析中解释结果数据的方法。
BACKGROUND: To date hydrocephalus researchers acknowledge the need for rigorous but utilitarian fluid mechanics understanding and methodologies in studying normal and hydrocephalic intracranial dynamics. Pressure volume models and electric circuit analogs introduced pressure into volume conservation; but control volume analysis enforces independent conditions on pressure and volume. Previously, utilization of clinical measurements has been limited to understanding of the relative amplitude and timing of flow, volume and pressure waveforms; qualitative approaches without a clear framework for meaningful quantitative comparison.METHODS: Control volume analysis is presented to introduce the reader to the theoretical background of this foundational fluid mechanics technique for application to general control volumes. This approach is able to directly incorporate the diverse measurements obtained by clinicians to better elucidate intracranial dynamics and progression to disorder.RESULTS: Several examples of meaningful intracranial control volumes and the particular measurement sets needed for the analysis are discussed.CONCLUSION: Control volume analysis provides a framework to guide the type and location of measurements and also a way to interpret the resulting data within a fundamental fluid physics analysis.