Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?
Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?
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DOI：
10.1002/acr.23608
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发表时间：
2018-11-01
影响因子：
4.7
通讯作者：
Loeser, Richard F.
中科院分区：
文献类型：
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作者：
Messier, Stephen P.;Resnik, Allison E.;Loeser, Richard F.
方法对“强化饮食和运动治疗关节炎”随机对照临床试验中单纯饮食诱导减肥（D）组和饮食诱导减肥加运动（D + E）组进行二次分析，以确定减肥对超重和肥胖成人膝关节骨关节炎（OA）临床和机制结局的剂量反应效应。240名参与者是超重和肥胖的社区老年人，患有疼痛和放射学膝关节OA。根据18个月内体重减轻的情况，将参与者分配到4组中的1组：
ObjectiveMethodsTo determine the dose response effect of weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis (OA).This is a secondary analysis of the diet-induced weight loss only (D) and diet-induced weight loss plus exercise (D + E) groups in the Intensive Diet and Exercise for Arthritis randomized controlled clinical trial. The 240 participants were overweight and obese older community-dwelling adults with pain and radiographic knee OA. Participants were assigned to 1 of 4 groups according to weight loss achieved over an 18-month period: