NMDA GLUTAMATERGIC RECEPTORS, LABELED WITH [H-3] MK-801, IN BRAIN SAMPLES FROM DRUG-FREE DEPRESSED SUICIDES
NMDA GLUTAMATERGIC RECEPTORS, LABELED WITH [H-3] MK-801, IN BRAIN SAMPLES FROM DRUG-FREE DEPRESSED SUICIDES
复制标题
DOI：
10.1016/0006-8993(93)90202-x
复制
发表时间：
1993-07-09
期刊：
影响因子：
2.9
通讯作者：
MALOTEAUX, JM
中科院分区：
文献类型：
--
作者：
HOLEMANS, S;DEPAERMENTIER, F;MALOTEAUX, JM
谷氨酸受体的NMDA-亚型定量结合[H-3]地佐环平马来酸盐（MK-801）在9个脑区从22个自杀受害者（20-60岁），与抑郁症的坚定的回顾性诊断，谁最近没有收到抗抑郁药，和20个年龄和性别匹配的控制。[H-3]MK-801结合在研究的任何地区的自杀者和对照组之间均无差异。暴力自杀者与非暴力自杀者和对照组没有区别。自杀者额叶皮层NMDA受体结合活性与年龄呈显著负相关，而对照组无相关性。这项初步研究几乎没有提供证据表明NMDA结合位点在抑郁症病理生理学中发挥重要作用。
Glutamate receptors of the NMDA-subtype were quantitated by binding of [H-3]dizocilpine maleate (MK-801) in nine brain regions from 22 suicide victims (20-60 yr), with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. [H-3]MK-801-binding did not differ between suicides and controls in any region studied. Suicides who died violently did not differ from non-violent suicides and controls. A significative negative correlation was found between age and NMDA receptor-binding in the frontal cortex of suicide victims, but not in controls. This preliminary study provides little evidence for an important role of NMDA-binding sites in the pathophysiology of depression.