Cortisol Levels in Children With Diabetic Ketoacidosis Associated With New-Onset Type 1 Diabetes Mellitus.
Cortisol Levels in Children With Diabetic Ketoacidosis Associated With New-Onset Type 1 Diabetes Mellitus.
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DOI：
10.1177/0009922816684595
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发表时间：
2017-02
影响因子：
1.6
通讯作者：
Aranoff GS
中科院分区：
文献类型：
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作者：
Williams KM;Fazzio P;Oberfield SE;Gallagher MP;Aranoff GS
尽管未经治疗的肾上腺皮质功能不全（AI）可能会使DKA的结局恶化，但很少有数据记录糖尿病酮症酸中毒（DKA）儿童的皮质醇水平。在这项横断面研究中，我们评估了28名DKA和新发1型糖尿病儿童的血清皮质醇水平，这些儿童在我们中心接受了5年的评估。糖尿病相关症状的平均持续时间与年龄正相关（P = .002），并且在最小的儿童中观察到血红蛋白A1 c水平显着较低。平均皮质醇水平为40.9 mg/dL，范围为7.8至119 mg/dL。皮质醇水平与血清pH值呈负相关（P = 0.007）。皮质醇水平低于18 mg/dL的4例患者的临床结局无差异。总的来说，我们没有发现皮质醇储备减少的临床或实验室证据;然而，在治疗DKA儿童时必须记住AI的可能性。
There is little data documenting cortisol levels in children with diabetic ketoacidosis (DKA), despite the fact that untreated adrenal insufficiency (AI) could worsen the outcome of DKA. In this cross-sectional study, we assessed serum cortisol levels in 28 children with DKA and new onset type 1 diabetes mellitus evaluated at our center over a 5-year period. Average duration of diabetes-related symptoms was positively associated with age (P = .002), and significantly lower hemoglobin A1c levels were observed in the youngest children. The mean cortisol level was 40.9 mg/dL, with a range of 7.8 to 119 mg/dL. Cortisol levels were found to be inversely associated with serum pH (P = .007). There was no difference in the clinical outcome of the 4 patients who had cortisol levels less than 18 mg/dL. Overall, we did not find clinical or laboratory evidence of diminished cortisol reserve; however, the possibility of AI must be kept in mind when treating children with DKA.