Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study.
Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study.
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DOI：
10.1016/j.cmi.2020.09.023
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Dong W
中科院分区：
文献类型：
--
作者：
Xiong Q;Xu M;Li J;Liu Y;Zhang J;Xu Y;Dong W
描述出院3个月以上的2019冠状病毒病（COVID-19）幸存者主要临床后遗症的患病率、性质和风险因素。这项纵向研究基于对2020年3月1日前在中国武汉市武汉大学人民医院住院和出院的COVID-19患者的电话随访调查。对幸存者的人口统计学和临床特征以及自我报告的临床后遗症进行了描述和分析。一组没有感染COVID-19并在疫情期间居住在武汉市区的志愿者也被选为对照组。在538名幸存者（293名，54.5%为女性）中，中位（四分位距）年龄为52.0（41.0-62.0）岁，从出院到首次随访的时间为97.0（95.0-102.0）天。临床后遗症常见，包括全身症状（n = 267，49.6%）、呼吸道症状（n = 210，39%）、心血管相关症状（n = 70，13%）、心理社会症状（n = 122，22.7%）和脱发（n = 154，28.6%）。我们发现体力下降/疲劳（p < 0.01）、活动后呼吸急促（p= 0.04）和脱发（p < 0.01）在女性受试者中比男性受试者更常见。住院期间呼吸困难与随后的体力下降/疲劳、活动后呼吸急促和静息心率增加相关，但与脱发无关。住院期间的哮喘史与随后的活动后呼吸急促后遗症相关。住院期间脉搏≥90 bpm的病史与恢复期静息心率增加相关。有体力下降/疲劳或活动后呼吸急促的幸存者在COVID-19发病后的病毒脱落持续时间和住院时间长于无此症状的幸存者。COVID-19早期恢复期的临床后遗症很常见;其中一些后遗症可能与性别、年龄和住院期间的临床特征有关。
To describe the prevalence, nature and risk factors for the main clinical sequelae in coronavirus disease 2019 (COVID-19) survivors who have been discharged from the hospital for more than 3 months. This longitudinal study was based on a telephone follow-up survey of COVID-19 patients hospitalized and discharged from Renmin Hospital of Wuhan University, Wuhan, China before 1 March 2020. Demographic and clinical characteristics and self-reported clinical sequelae of the survivors were described and analysed. A cohort of volunteers who were free of COVID-19 and lived in the urban area of Wuhan during the outbreak were also selected as the comparison group. Among 538 survivors (293, 54.5% female), the median (interquartile range) age was 52.0 (41.0–62.0) years, and the time from discharge from hospital to first follow-up was 97.0 (95.0–102.0) days. Clinical sequelae were common, including general symptoms (n = 267, 49.6%), respiratory symptoms (n = 210, 39%), cardiovascular-related symptoms (n = 70, 13%), psychosocial symptoms (n = 122, 22.7%) and alopecia (n = 154, 28.6%). We found that physical decline/fatigue (p < 0.01), postactivity polypnoea (p= 0.04) and alopecia (p < 0.01) were more common in female than in male subjects. Dyspnoea during hospitalization was associated with subsequent physical decline/fatigue, postactivity polypnoea and resting heart rate increases but not specifically with alopecia. A history of asthma during hospitalization was associated with subsequent postactivity polypnoea sequela. A history of pulse ≥90 bpm during hospitalization was associated with resting heart rate increase in convalescence. The duration of virus shedding after COVID-19 onset and hospital length of stay were longer in survivors with physical decline/fatigue or postactivity polypnoea than in those without. Clinical sequelae during early COVID-19 convalescence were common; some of these sequelae might be related to gender, age and clinical characteristics during hospitalization.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
39
作者：
Wu, Chaomin;Chen, Xiaoyan;Song, Yuanlin
通讯作者：
Song, Yuanlin
影响因子：
15.1
作者：
Chew, Nicholas W. S.;Lee, Grace K. H.;Sharma, Vijay K.
通讯作者：
Sharma, Vijay K.
中国武汉市 138 例 2019 新型冠状病毒感染肺炎住院患者的临床特征。
影响因子：
120.7
作者：
Wang, Dawei;Hu, Bo;Peng, Zhiyong
通讯作者：
Peng, Zhiyong
影响因子：
4.4
作者：
Chaves, C.;Castellanos, T.;Vazquez, Carmelo
通讯作者：
Vazquez, Carmelo