Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior
Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior
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DOI：
10.1007/s13668-019-0276-z
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发表时间：
2019-06-01
影响因子：
4.9
通讯作者：
Pothos, Emmanuel N.
中科院分区：
文献类型：
--
作者：
Kleinridders, Andre;Pothos, Emmanuel N.
综述目的饮食肥胖主要归因于食物摄入量和能量消耗之间的不平衡。坚持生活方式干预减肥的比例通常较低。结果，肥胖成为一种慢性状态，胰岛素抵抗和糖尿病等并存疾病增加。我们综述了大脑胰岛素作用和多巴胺能信号传递对食物摄入量、奖赏和情绪的影响，以及这些系统对抗肥胖流行的潜在调节。最近的研究发现，中枢胰岛素和多巴胺的作用是相互关联的，并影响食物摄取、奖赏和情绪。大脑胰岛素抵抗会导致吞噬过度、焦虑和抑郁样行为，并损害多巴胺能系统。这种影响可能会导致患者对医疗的依从性降低。胰岛素受体敏化和多巴胺受体激动剂在啮齿动物和人类中显示出减轻肥胖和改善心理健康的作用。总之，调节肥胖患者的大脑胰岛素和多巴胺信号可以潜在地改善治疗结果。
Purpose of Review Dietary obesity is primarily attributed to an imbalance between food intake and energy expenditure. Adherence to lifestyle interventions reducing weight is typically low. As a result, obesity becomes a chronic state with increased co-morbidities such as insulin resistance and diabetes. We review the effects of brain insulin action and dopaminergic signal transmission on food intake, reward, and mood as well as potential modulations of these systems to counteract the obesity epidemic.Recent Findings Central insulin and dopamine action are interlinked and impact on food intake, reward, and mood. Brain insulin resistance causes hyperphagia, anxiety, and depressive-like behavior and compromises the dopaminergic system. Such effects can induce reduced compliance to medical treatment. Insulin receptor sensitization and dopamine receptor agonists show attenuation of obesity and improvement of mental health in rodents and humans.Summary Modulating brain insulin and dopamine signaling in obese patients can potentially improve therapeutic outcomes.