Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke - The Framingham offspring study
Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke - The Framingham offspring study
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DOI：
10.1001/archinte.166.1.106
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发表时间：
2006-01-09
影响因子：
--
通讯作者：
Wolf, PA
中科院分区：
文献类型：
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作者：
Najarian, RM;Sullivan, LM;Wolf, PA
背景：代谢综合征(METS)已被认为是糖尿病前期症状和心血管疾病的独立危险因素。方法：为了评估年龄调整后的卒中风险和与METS相关的人群归因风险，并与显性2型糖尿病(以下简称糖尿病)进行比较，我们在Framingham子代研究中确定了2097名年龄在50-81岁且无卒中的受试者的METS、糖尿病和两者的患病率。结果：30.3%的男性和24.7%的女性符合METS标准。24%的男性只患有MET，7%的男性单独患有糖尿病，6%的男性两者都有。20%的女性只患有MET，3%的女性单独患有糖尿病，5%的女性两者都有。在14年的随访中，75名男性和55名女性发生了首次中风；除4例外，所有事件都是缺血性的。同时患有糖尿病和METS的患者发生中风的相对风险(RR)(RR，3.28；可信区间[CI]，1.82-5.92)高于单独患有任何一种疾病的患者(单独患有METS：RR，2.10；CI，1.37-3.22；单独糖尿病：RR，2.47；CI，1.31-4.65)。由于代谢综合征的患病率更高，因此单独患代谢综合征的人群归因风险比单独患糖尿病的风险更大(19%比7%)，特别是在女性中(27%比5%)。结论：代谢综合征比糖尿病更常见，是非糖尿病人群卒中的重要独立危险因素。预防和控制蛋氨酸及其成分可能会降低中风的发生率。
Background: Metabolic syndrome (MetS) has been recognized as a prediabetic constellation of symptoms and an independent risk factor for cardiovascular disease.Methods: To evaluate the age-adjusted risk of stroke and population-attributable risk associated with MetS and compare with those of overt type 2 diabetes mellitus (hereinafter, "diabetes"), we determined the prevalence of MetS alone, diabetes alone, and both in 2097 subjects in the Framingham Offspring Study, aged 50 to 81 years and free of stroke. Age-adjusted risk ratios, 10-year incidence, and population-attributable risks of stroke were estimated for men and women with MetS alone, diabetes alone, and both.Results: Criteria for MetS were met in 30.3% of men and 24.7% of women. Twenty-four percent of men had MetS alone; 7% had diabetes alone; and 6% had both. Twenty percent of women had MetS alone; 3% had diabetes alone; and 5% had both. Over 14 years of follow-up, 75 men and 55 women developed a first stroke; all but 4 events were ischemic. Relative risk (RR) of stroke in persons with both diabetes and MetS (RR, 3.28; confidence interval [CI], 1.82-5.92) was higher than that for either condition alone (MetS alone: RR, 2.10; CI, 1.37-3.22; diabetes alone: RR, 2.47; CI, 1.31-4.65). The population-attributable risk, owing to its greater prevalence, was greater for MetS alone than for diabetes alone (19% vs 7%), particularly in women (27% vs 5%).Conclusions: Metabolic syndrome is more prevalent than diabetes and a significant independent risk factor for stroke in people without diabetes. Prevention and control of MetS and its components are likely to reduce stroke incidence.