Oncogenic MicroRNAs: Key Players in Malignant Transformation.
Oncogenic MicroRNAs: Key Players in Malignant Transformation.
复制标题
致癌 MicroRNA：恶性转化的关键参与者。
DOI：
10.3390/cancers7040904
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发表时间：
2015-12-18
期刊：
影响因子：
5.2
通讯作者：
Blandino G
中科院分区：
文献类型：
--
作者：
Frixa T;Donzelli S;Blandino G
MicroRNAs(MiRNAs)是一类非编码RNA，在转录后水平的基因表达调控中发挥着关键作用。MiRNAs参与许多生物学过程，其表达的轻微调节与不同疾病的发生有关。特别是，具有致癌或抑癌功能的miRNAs的表达变化与肿瘤的发生、恶性转化、转移和抗癌治疗的反应有关。本文将主要对其异常表达导致恶性转化的致癌miRNAs进行综述。
MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.