New Metrics for Evaluating Viral Respiratory Pathogenesis
New Metrics for Evaluating Viral Respiratory Pathogenesis
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DOI：
10.1371/journal.pone.0131451
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发表时间：
2015-06-26
期刊：
影响因子：
3.7
通讯作者：
Ferris, Martin T.
中科院分区：
文献类型：
--
作者：
Menachery, Vineet D.;Gralinski, Lisa E.;Ferris, Martin T.
在小鼠中进行的病毒发病机制研究依赖于严重全身性疾病的标志物，而不是临床相关指标来评价呼吸道病毒感染;因此混淆了与人类疾病的联系。在这里，全身体积描记法被用来直接测量两种呼吸道病毒感染期间肺功能的变化。该方法密切跟踪传统的发病机制指标，区分病毒和剂量特异性反应，并确定了SARS冠状病毒和甲型流感病毒感染后的长期呼吸变化。总之，这项工作突出了检查感染后呼吸功能的实用性，以充分了解病毒的发病机制。
Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.