Social and ethical issues in mitochondrial donation
Social and ethical issues in mitochondrial donation
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DOI：
10.1093/bmb/ldv037
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发表时间：
2015-09-01
影响因子：
6.7
通讯作者：
Dimond, Rebecca
中科院分区：
文献类型：
--
作者：
Dimond, Rebecca
简介或背景：英国处于线粒体科学的前沿，是目前世界上唯一将涉及线粒体捐赠的种系技术合法化的国家。然而，人们对基因改造和设计婴儿的“滑坡”提出了担忧。数据来源：本综述使用了学术文章、报纸报告和公开文件。一致的领域：线粒体捐赠为患有线粒体疾病的女性提供了生育健康、遗传相关的孩子的机会。争议的领域：主要分歧领域包括安全性、三亲婴儿的创造、对身份的影响、影响 发展点：英国政府于 2015 年 3 月使该技术合法化。世界各地的科学界和医学界饶有兴趣地关注着这一进展。适时开展研究的领域：预计第一批“三亲”婴儿将于 2016 年在英国出生。他们的健康和进展将受到密切监测。
Introduction or background: The UK is at the forefront of mitochondrial science and is currently the only country in the world to legalize germ-line technologies involving mitochondrial donation. However, concerns have been raised about genetic modification and the 'slippery slope' to designer babies.Sources of data: This review uses academic articles, newspaper reports and public documents.Areas of agreement: Mitochondrial donation offers women with mitochondrial disease an opportunity to have healthy, genetically related children.Areas of controversy: Key areas of disagreement include safety, the creation of three-parent babies, impact on identity, implications for society, definitions of genetic modification and reproductive choice.Growing points: The UK government legalized the techniques in March 2015. Scientific and medical communities across the world followed the developments with interest.Areas timely for developing research: It is expected that the first cohort of 'three parent' babies will be born in the UK in 2016. Their health and progress will be closely monitored.