STAT1-dependent innate immunity to a Norwalk-like virus
STAT1-dependent innate immunity to a Norwalk-like virus
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DOI：
10.1126/science.1077905
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发表时间：
2003-03-07
期刊：
影响因子：
56.9
通讯作者：
Virgin, HW
中科院分区：
文献类型：
--
作者：
Karst, SM;Wobus, CE;Virgin, HW
全球90%以上的非细菌性流行性胃肠炎是由诺瓦克样杯状病毒引起的，但诺沃克病毒感染的发病机制尚不清楚，因为这些病毒不能在培养细胞中生长，也没有小动物模型。在这里，我们报告了一种以前未知的老鼠诺沃克病毒。对小鼠诺如病毒1型感染的分析表明，信号转导和转录激活因子1依赖的先天免疫，而不是T和B细胞依赖的获得性免疫，是诺如病毒抵抗所必需的。鉴定对小鼠诺如病毒耐药至关重要的宿主分子可能为预防或控制一种重要的人类疾病提供靶点。
Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.