Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: a retrospective cohort study
Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: a retrospective cohort study
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DOI：
10.1136/bmjopen-2015-010210
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发表时间：
2016-01-01
期刊：
影响因子：
2.9
通讯作者：
Petersent, Irene
中科院分区：
文献类型：
--
作者：
Sharma, Manuj;Nazareth, Irwin;Petersent, Irene
目的：调查 2000 年至 2013 年间 2 型糖尿病 (T2DM) 的发病率和流行诊断趋势及其药物治疗。设计：对健康改善网络 (THIN) 初级保健数据库中的纵向电子健康记录进行分析。背景：英国初级保健。参与者：我们总共检查了 8 838 031 名 0-99 岁的个体。结果指标：2013 年间 T2DM 的发病率和患病率2000 年和 2013 年，并审查了年龄、性别和社会剥夺对这些措施的影响。还调查了 2000 年至 2013 年间抗糖尿病治疗处方模式的变化。结果：总体而言，有 406 344 人被诊断为 T2DM，其中 203 639 人在 2000 年至 2013 年间新诊断。T2DM 的发病率从每 1000 人年风险 (PYAR) 3.69 人上升（95% CI男性中，2000 年每 1000 PYAR 为 3.58 至 3.81），2013 年为 3.99（95% CI 3.90 至 4.08）；女性中，从每 1000 PYAR 3.06（95% CI 2.95 至 3.17）增加到每 1000 PYAR 3.73（95% CI 3.65 至 3.82）。 T2DM 患病率增加了一倍多，从 2000 年的 2.39%（95% CI 2.37 至 2.41）增加到 2013 年的 5.32%（95% CI 5.30 至 5.34）。男性、年龄较大和来自社会贫困地区与 T2DM 密切相关（p
Objective: To investigate trends in incident and prevalent diagnoses of type 2 diabetes mellitus (T2DM) and its pharmacological treatment between 2000 and 2013.Design: Analysis of longitudinal electronic health records in The Health Improvement Network (THIN) primary care database.Setting: UK primary care.Participants: In total, we examined 8 838 031 individuals aged 0-99 years.Outcome measures: The incidence and prevalence of T2DM between 2000 and 2013, and the effect of age, sex and social deprivation on these measures were examined. Changes in prescribing patterns of antidiabetic therapy between 2000 and 2013 were also investigated.Results: Overall, 406 344 individuals had a diagnosis of T2DM, of which 203 639 were newly diagnosed between 2000 and 2013. The incidence of T2DM rose from 3.69 per 1000 person-years at risk (PYAR) (95% CI 3.58 to 3.81) in 2000 to 3.99 per 1000 PYAR (95% CI 3.90 to 4.08) in 2013 among men; and from 3.06 per 1000 PYAR (95% CI 2.95 to 3.17) to 3.73 per 1000 PYAR (95% CI 3.65 to 3.82) among women. Prevalence of T2DM more than doubled from 2.39% (95% CI 2.37 to 2.41) in 2000 to 5.32% (95% CI 5.30 to 5.34) in 2013. Being male, older, and from a more socially deprived area was strongly associated with having T2DM, (p