Adipose tissue radiodensity: A new prognostic biomarker in people with multiple myeloma
Adipose tissue radiodensity: A new prognostic biomarker in people with multiple myeloma
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DOI：
10.1016/j.nut.2021.111141
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发表时间：
2021-02-15
期刊：
影响因子：
4.4
通讯作者：
Carvalheira, Jose Barreto Campello
中科院分区：
文献类型：
--
作者：
da Cunha, Ademar Dantas, Jr.;Silveira, Marina Nogueira;Carvalheira, Jose Barreto Campello
目的：基于多发性骨髓瘤（MM）个体特征的标准预后标志物仍然很少。身体组成特征通常与不同癌症的生存结果有关。然而，脂肪组织放射密度与MM预后的关联尚未，据我们所知，been explored.Methods：在第三腰椎计算机断层扫描被用于身体成分分析，包括脂肪组织放射密度，在91人MM。此外，氟脱氧葡萄糖F18（F-18-FDG）正电子发射断层扫描被用来评估脂肪组织F-18-FDG摄取。结果：高皮下脂肪组织（SAT）放射密度参与者的无事件生存期和总生存期均较短。SAT放射密度最高三分位数的患者的总生存率（风险比，4.55; 95%置信区间，1.26-16.44; P趋势= 0.036）和无事件生存率（风险比，3.08; 95%置信区间，1.02-9.27; P趋势= 0.035）均独立较高。重要的是，较高的SAT放射密度显着相关增加F-18-FDG脂肪组织摄取和促炎细胞因子（肿瘤坏死因子和白细胞介素-6）水平，并与降低leptin levels.Conclusions：SAT放射密度可以作为一个生物标志物来预测主机相关的代谢和促炎环境，最终与MM预后。(C)2021爱思唯尔公司All rights reserved.
Objectives: Standard prognostic markers based on individual characteristics of individuals with multiple myeloma (MM) remain scarce. Body-composition features have often been associated with survival outcomes in different cancers. However, the association of adipose tissue radiodensity with MM prognosis has not yet, to our knowledge, been explored.Methods: Computed tomography at the third lumbar vertebra was used for body-composition analysis, including adipose tissue radiodensity, in 91 people with MM. Additionally, fludeoxyglucose F 18 (F-18-FDG) positron emission tomography was used to assess adipose tissue F-18-FDG uptake. Proinflammatory cytokine and adipokine levels were measured.Results: Event-free survival and overall survival were both shorter in participants with high subcutaneous adipose tissue (SAT) radiodensity. Those in the highest SAT radiodensity tertile had an independently higher risk for both overall survival (hazard ratio, 4.55; 95% confidence interval, 1.26-16.44; P-trend = 0.036) and event-free survival (hazard ratio, 3.08; 95% confidence interval, 1.02-9.27; P-trend = 0.035). Importantly, higher SAT radiodensity was significantly correlated with increased F-18-FDG adipose tissue uptake and proinflammatory cytokine (tumor necrosis factor and interleukin-6) levels, and with decreased leptin levels.Conclusions: SAT radiodensity may serve as a biomarker to predict host-related metabolic and proinflammatory milieu, which ultimately correlates with MM prognosis. (C) 2021 Elsevier Inc. All rights reserved.