Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.
Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.
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DOI：
10.1016/j.bbrc.2012.06.050
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发表时间：
2012-07-06
影响因子：
3.1
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Yao Y;Fan Y;Wu J;Wan H;Wang J;Lam S;Lam WL;Girard L;Gazdar AF;Wu Z;Zhou Q
鉴定一组肿瘤相关自身抗体，该抗体可作为非小细胞肺癌（NSCLC）早期诊断的生物标志物。分离到35个独特的和框内表达的噬菌体蛋白。基于基因表达谱，选择了4个蛋白进行进一步研究。受体工作特性曲线分析和留一法均表明，联合测量产生的四种抗体比单独使用任何单一标记具有更好的预测准确性。留一验证也显示与所有阶段的NSCLC患者有显著相关性。自身抗体组对早期非小细胞肺癌的检测具有很高的潜力。
To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.