HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women
HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women
复制标题
DOI：
10.1093/jnci/djw100
复制
发表时间：
2016-09-01
影响因子：
10.3
通讯作者：
Schiffman, Mark
中科院分区：
文献类型：
--
作者：
Mirabello, Lisa;Yeager, Meredith;Schiffman, Mark
背景：HPV16是一种常见的性传播感染，尽管很少有感染会导致宫颈癌前期/癌症；我们无法区分也无法机械地解释为什么只有某些感染会进展。 HPV16 可分为四种主要的进化衍生变异谱系（A、B、C、D），之前已被认为具有不同的疾病风险。方法：我们使用高通量 HPV16 全基因组测序分析来调查 3215 名 HPV16 感染女性的变异谱系风险。使用亚谱系 A1/A2 作为参考，我们在三年或更长时间的随访中评估了所有变异谱系与感染结果的关联：1107 名对照受试者（
Background: HPV16 is a common sexually transmitted infection although few infections lead to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only certain infections progress. HPV16 can be classified into four main evolutionary-derived variant lineages (A, B, C, D) that have been previously suggested to have varying disease risks.Methods: We used a high-throughput HPV16 whole-genome sequencing assay to investigate variant lineage risk among 3215 HPV16-infected women. Using sublineages A1/A2 as the reference, we assessed all variant lineage associations with infection outcome over three or more years of follow-up: 1107 control subjects (