Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network
Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network
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DOI：
10.1136/archdischild-2019-316816
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发表时间：
2020-01-01
影响因子：
5.2
通讯作者：
Sharland, Michael
中科院分区：
文献类型：
--
作者：
Li, Grace;Bielicki, Julia Anna;Sharland, Michael
目的了解低收入和中等收入国家（LMIC）新生儿单位（NNUs）之间可用资源和临床实践的差异，以指导设计一项关于单位水平抗生素耐药性（AMR）负担的观察性研究。设计使用REDCap数据库的基于网络的调查分发给参与新生儿AMR研究网络的NNUs。调查内容包括NNU的资金结构、规模、入学率、支持性治疗的获得，新生儿血培养分离株及其耐药模式的经验性抗菌指南和时期患病率。设置来自12个国家的39个NNUs。患者任何新生儿入住其中一个参与NNUs。干预措施这是一项观察性队列研究。结果每个单位的活产数范围为513至在12个月的研究期间，27700名新生儿，新生儿婴儿床的数量从12到110不等。早产儿的比例
Objective To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR).Design A web-based survey using a REDCap database was circulated to NNUs participating in the Neonatal AMR research network. The survey included questions about NNU funding structure, size, admission rates, access to supportive therapies, empirical antimicrobial guidelines and period prevalence of neonatal blood culture isolates and their resistance patterns.Setting 39 NNUs from 12 countries.Patients Any neonate admitted to one of the participating NNUs.Interventions This was an observational cohort study.Results The number of live births per unit ranged from 513 to 27 700 over the 12-month study period, with the number of neonatal cots ranging from 12 to 110. The proportion of preterm admissions