A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans
A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans
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DOI：
10.1016/j.devcel.2015.02.015
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发表时间：
2015-05-04
影响因子：
11.8
通讯作者：
Han, Min
中科院分区：
文献类型：
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作者：
Kniazeva, Marina;Zhu, Huanhu;Han, Min
食物匮乏抑制动物的生长和发育，但对觅食至关重要的系统却没有影响。这种选择性发育的机制以及脂质在其中的潜在作用尚不清楚。当C.线虫在无食物的环境中孵化，胚后生长和发育停滞，但食物反应所需的感觉神经元分化和神经元发育继续。在这里，我们表明，单甲基支链脂肪酸（mmBCFAs）和它们的衍生物，d17异葡萄糖神经酰胺，在肠道功能，以促进觅食行为和感觉神经元的成熟，通过两个TORC 1依赖和独立的机制。我们发现，mmBCFA影响的一个子集的基因，包括ceh-36/Hox，我们表明，发挥关键作用，在介导调节神经元功能的脂质途径的表达。这项研究揭示了一种脂质通路促进了进食和禁食条件下参与觅食的神经元功能，并为TORC 1的生理功能提供了重要的见解。
Food deprivation suppresses animal growth and development but spares the systems essential for foraging. The mechanisms underlying this selective development, and potential roles of lipids in it, are unclear. When C. elegans hatch in a food-free environment, postembryonic growth and development stall, but sensory neuron differentiation and neuronal development required for food responses continue. Here, we show that monomethyl branched-chain fatty acids (mmBCFAs) and their derivative, d17isoglucosylceramide, function in the intestine to promote foraging behavior and sensory neuron maturation through both TORC1-dependent and -independent mechanisms. We show that mmBCFAs impact the expression of a subset of genes, including ceh-36/Hox, which we show to play a key role in mediating the regulation of the neuronal functions by this lipid pathway. This study uncovers that a lipid pathway promotes neuronal functions involved in foraging under both fed and fasting conditions and adds critical insight into the physiological functions of TORC1.