Telomere Length and Pulse Pressure in Newly Diagnosed, Antipsychotic-Naive Patients With Nonaffective Psychosis
Telomere Length and Pulse Pressure in Newly Diagnosed, Antipsychotic-Naive Patients With Nonaffective Psychosis
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DOI：
10.1093/schbul/sbn169
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发表时间：
2009-03-01
影响因子：
6.6
通讯作者：
Kirkpatrick, Brian
中科院分区：
文献类型：
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作者：
Fernandez-Egea, Emilio;Bernardo, Miguel;Kirkpatrick, Brian
前言：最近的研究表明，除了治疗副作用、自杀和不良健康习惯等因素外，精神分裂症患者在接受抗精神病药物治疗之前患糖尿病的风险可能会增加。糖尿病与脉压升高(PP)和端粒缩短有关。我们测试了这一假设，即在抗精神病药物治疗之前，精神分裂症和相关疾病与端粒缩短和PP增加有关。方法：对初诊、未服用抗精神病药的精神分裂症及相关疾病患者首次临床接触时的端粒含量(与端粒长度高度相关)和PP进行测定，并与对照组进行比较。两组都接受了口服葡萄糖耐量试验。结果：与对照组相比，精神病患者端粒含量降低，PP升高。正如之前报道的那样，他们在2小时内也有葡萄糖浓度升高。这些差异不能归因于年龄、种族、吸烟、性别、体重指数、居住社区、社会经济状况、有氧条件或精神病受试者皮质醇浓度增加的差异。讨论：这些结果表明，在使用抗精神病药物之前，非情感性精神病与端粒含量减少和PP增加有关，这些指数与糖尿病和高血压的风险增加有关。
Introduction: Recent studies suggest that in addition to factors such as treatment side effects, suicide, and poor health habits, people with schizophrenia may have an increased risk of diabetes prior to antipsychotic treatment. Diabetes is associated with an increased pulse pressure (PP) and a shortened telomere. We tested the hypothesis that prior to antipsychotic treatment, schizophrenia and related disorders are associated with a shortened telomere, as well as an increased PP. Methods: Telomere content (which is highly correlated with telomere length) and PP were measured in newly diagnosed, antipsychotic-naive patients with schizophrenia and related disorders on first clinical contact and in matched control subjects. Both groups were also administered an oral glucose tolerance test. Results: Compared with control subjects, the patients with psychosis had decreased telomere content and an increased PP. As previously reported, they also had increased glucose concentrations at 2 hours. These differences could not be attributed to differences in age, ethnicity, smoking, gender, body mass index, neighborhood of residence, socioeconomic status, aerobic conditioning, or an increased cortisol concentration in the psychotic subjects. Discussion: These results suggest that prior to antipsychotic use, nonaffective psychosis is associated with reduced telomere content and increased PP, indices that have been linked to an increased risk of diabetes and hypertension.