The effects of prolonged infusion of the dog's pancreas with glucose.
The effects of prolonged infusion of the dog's pancreas with glucose.
复制标题
长期向狗的胰腺输注葡萄糖的影响。
DOI：
10.1210/endo-50-6-644
复制
发表时间：
1952
期刊：
影响因子：
4.8
通讯作者：
F. Lukens
中科院分区：
文献类型：
--
作者：
E. M. Brown;F. Dohan;L. R. Freedman;P. D. de Moor;F. Lukens
反复向猫的腹膜内注射葡萄糖会导致朗格汉斯岛严重的水变性和永久性糖尿病(Dohan和Lukens，1948)。由此产生的长期、持续的高血糖被认为是导致水化改变和持续性糖尿病的最重要因素。为了进一步测试这种可能性，似乎希望将持续的高血糖定位于胰腺或胰腺的一部分。通过这种方式，可以避免对全身性高血糖的反应，而在输注器官中发现的变化可能归因于局部高血糖。在本文报道的实验中，成功地将一部分胰腺与葡萄糖一起注入通常会导致全身性低血糖和朗格汉斯岛的变化，包括增生和水变性。糖尿病没有发生，也没有预料到，因为只有一部分胰腺被注入。
SEVERE hydropic degeneration of the islands of Langerhans and permanent diabetes have been produced in cats by repeated intraperitoneal injections of glucose (Dohan and Lukens, 1948). The prolonged, sustained hyperglycemia so produced was thought to be the most important factor in the production of the hydropic change and the persistent diabetes. To test further this possibility it seemed desirable to localize a sustained hyperglycemia to the pancreas or a portion of it. In this way the responses to systemic hyperglycemia might be avoided and changes found in the infused organ might be attributed to the local hyperglycemia. In the experiments reported herein, the successful infusion of a part of the pancrease with glucose usually resulted in systemic hypoglycemia and in changes in the islands of Langerhans which includes both hyperplasia and hydropic degeneration. Diabetes did not occur, nor was it expected, since only part of the pancreas was infused.