Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer
Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer
复制标题
DOI：
10.1097/01.ncc.0000265004.64440.5f
复制
发表时间：
2007-03-01
期刊：
影响因子：
2.6
通讯作者：
McKenzie, D. C.
中科院分区：
文献类型：
--
作者：
Campbell, K. L.;Lane, K.;McKenzie, D. C.
体重增加是辅助化疗的常见副作用。治疗期间静息能量消耗的变化已被认为是体重增加的机制。我们前瞻性地测量了10名接受乳腺癌辅助化疗的女性的静息能量消耗、体重变化和身体成分（双能x线吸收法）。在化疗周期之间（P = 0.78）或从基线到治疗结束（1，189.68 +/- 80.27 vs 1，205.76 +/- 56.71 kcal/d; P = 0.74），静息能量消耗没有变化。总体而言，参与者在治疗期间没有增加体重。然而，体重增加的总体趋势（66.3 +/- 5.1 vs 68.2 +/- 5.0 kg; P = 0.09），参与者的总脂肪量确实增加（24.2 +/- 3.8 vs 26.5 +/- 3.2 kg; P = 0.04），而肌肉量保持不变。虽然没有观察到静息能量消耗的变化，但观察到的总脂肪量增加与乳腺癌辅助化疗治疗中通常报告的体力活动水平降低一致，这些身体成分变化可能对幸存者具有重要的健康意义。
Weight gain is a commonly reported side effect of adjuvant chemotherapy. A change in resting energy expenditure during treatment has been a suggested mechanism for weight gain. We prospectively measured resting energy expenditure, weight change, and body composition (dual-energy x-ray absorptiometry) in 10 women undergoing adjuvant chemotherapy for breast cancer. There was no change in resting energy expenditure across cycles of chemotherapy (P =.78) or from baseline to the end of treatment (1, 189.68 +/- 80.27 vs 1,205.76 +/- 56.71 kcal/d; P =.74). Overall, participants did not gain weight across treatment. However, there was an overall trend toward weight gain (66.3 +/- 5.1 vs 68.2 +/- 5.0 kg; P =.09), and participants did show an increase in total fat mass (24.2 +/- 3.8 vs 26.5 +/- 3.2 kg; P =.04), whereas muscle mass remained the same. Although no change in resting energy expenditure was seen, the observed increase in total fat mass is consistent with a decrease in physical activity level commonly reported with adjuvant chemotherapy treatment of breast cancer, and these body composition changes may have important health implications for survivors.