A morning surge in plasma luteinizing hormone coincides with elevated Fos expression in gonadotropin-releasing hormone-immunoreactive neurons in the diurnal rodent, Arvicanthis niloticus.
A morning surge in plasma luteinizing hormone coincides with elevated Fos expression in gonadotropin-releasing hormone-immunoreactive neurons in the diurnal rodent, Arvicanthis niloticus.
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早晨血浆黄体生成素的激增与日间啮齿动物 Arvicanthis niloticus 中促性腺激素释放激素免疫反应性神经元中 Fos 表达的升高同时发生。
DOI：
10.1095/biolreprod61.4.1115
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发表时间：
1999
影响因子：
3.6
通讯作者：
Smale,L
中科院分区：
文献类型：
--
作者：
McElhinny,TL;Sisk,CL;Holekamp,KE;Smale,L
来自撒哈拉以南非洲的一种昼夜活动的啮齿动物。在这里，我们报告了与交配有关的过程，试图阐明控制时间组织的神经机制在夜间和白天的物种中是如何不同的。首先，我们系统地绘制了成年女性GnRH神经元的分布。其次，我们验证了一种假设，即在LH激增的时间和gnrh免疫反应性（IR）神经元中Fos表达的相关增加方面，arvicanthiss与夜间啮齿类动物不同。我们在产后发情时检查了这些事件。当分娩发生在授时时间（ZT） 2和17之间（灯在ZT 0打开，ZT 12关闭；每天有24个ZT单位，每个单位相当于1个标准小时），我们在ZT 17、20、23和2采集血液并灌注雌性。血浆LH在zt20出现一个尖峰，在zt17和zt20之间表达Fos-IR的GnRH-IR神经元的百分比增加了10倍。相比之下，夜间活动的啮齿动物在光照期的最后几个小时出现这种上升。这是第一个表明夜行动物和昼行动物在与已知重要的精确时间事件相关的神经机制方面存在差异的迹象。
Arvicanthis niloticusis a diurnal murid rodent from sub-Saharan Africa. Here we report on processes associated with mating in this species in an attempt to elucidate how the neural mechanisms governing temporal organization differ in nocturnal and diurnal species. First, we systematically mapped the distribution of GnRH neurons in adult females. Second, we tested the hypothesis thatArvicanthisdiffer from nocturnal murid rodents with respect to the timing of the LH surge and the associated increase in Fos expression in GnRH-immunoreactive (IR) neurons. We examined these events around a postpartum estrus. When parturition occurred between zeitgeber time (ZT) 2 and 17 (lights on at ZT 0 and off at ZT 12; there are 24 ZT units a day, each equivalent to 1 standard hour), we collected blood and perfused females at ZT 17, 20, 23, or 2. A sharp peak in plasma LH occurred at ZT 20, and a 10-fold increase in the percentage of GnRH-IR neurons that expressed Fos-IR occurred between ZT 17 and 20. By contrast, this rise occurs in nocturnal rodents during the last few hours of the light period. This is the first indication of a difference between nocturnal and diurnal animals with respect to neural mechanisms associated with a precisely timed event of known significance.