Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis
Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis
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DOI：
10.3945/ajcn.112.054502
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发表时间：
2013-06-01
影响因子：
7.1
通讯作者：
de Boer, Ian H.
中科院分区：
文献类型：
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作者：
Sachs, Michael C.;Shoben, Abigail;de Boer, Ian H.
背景：与平均值相比，循环中25-羟基维生素D[25(OH)D]浓度的季节变化较大。单次测量可能会对年度暴露进行错误分类，这可能会导致研究中的偏差，并使临床决策复杂化。目的：我们旨在开发和验证一种模型，用于将血清25(OH)D浓度的单次测量调整到一年中的测量时间。设计：我们使用质谱仪测量了来自动脉粥样硬化多种族研究的6476名参与者的血清25(OH)D浓度，并在中位数17个月后再次测量了368名参与者的子集。结果：受试者的平均年龄为62.1岁，其中61.2%为非白人，53.3%为女性。COSINOR模型预测随访的25(OH)D浓度比单次测量更好[均方根误差差：1.3ng.ml1；P<；0.001]。余弦模型也更好地预测了测得的年平均25(OH)D浓度(均方根误差：1.0 ng/mL；P<；0.001)。根据COSINOR模型估计的年平均25(OH)D浓度将7.1%的参与者重新归类为25(OH)D缺乏，这被定义为
Background: The seasonal variation in circulating 25-hydroxyvitamin D [25(OH)D] concentrations is large relative to mean values. Single measurements may misclassify annual exposure, which may lead to bias in research and complicate clinical decision making.Objective: We aimed to develop and validate a model for adjusting a single measurement of a serum 25(OH)D concentration to the time of year it was measured.Design: We measured serum 25(OH)D concentrations by using mass spectrometry in 6476 participants from the Multi-Ethnic Study of Atherosclerosis at baseline and again in a subset of 368 participants at a median of 17 mo later. We estimated a cosinor model to describe the seasonal variability in 25(OH)D concentrations and evaluated this model by using follow-up 25(OH)D measurements.Results: The mean age of subjects was 62.1 y, 61.2% of participants were nonwhite, and 53.3% of participants were women. The cosinor model predicted follow-up 25(OH)D concentrations better than a single measurement [difference in root mean squared error (RMSE): 1.3 ng/mL; P < 0.001]. The cosinor model also better predicted the measured annual mean 25(OH)D concentration (difference in RMSE: 1.0 ng/mL; P < 0.001). Annual mean 25(OH)D concentrations estimated from the cosinor model reclassified 7.1% of participants with regard to 25(OH)D deficiency, which was defined as