Multiparametric Magnetic Resonance Imaging of the Prostate: Repeatability of Volume and Apparent Diffusion Coefficient Quantification.
Multiparametric Magnetic Resonance Imaging of the Prostate: Repeatability of Volume and Apparent Diffusion Coefficient Quantification.
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DOI：
10.1097/rli.0000000000000382
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发表时间：
2017-09
影响因子：
6.7
通讯作者：
Fennessy FM
中科院分区：
文献类型：
--
作者：
Fedorov A;Vangel MG;Tempany CM;Fennessy FM
补充数字内容可在文本中找到。本研究的目的是评价使用直肠内线圈获得的前列腺标准护理3 T多参数磁共振成像（mpMRI）中感兴趣区（ROI）体积和平均表观扩散系数（ADC）的可重复性。这项前瞻性研究符合《健康保险携带和责任法案》，获得了机构审查委员会的批准和书面知情同意书。计划进行mpMRI的确诊或疑似未经治疗的前列腺癌男性在2周内接受重复mpMRI。使用前列腺成像报告和数据系统（PI-RADS）v2对轴向T2加权、动态对比增强减影和ADC图像上对应于整个前列腺、整个外周区（PZ）、正常PZ和疑似肿瘤ROI（tROI）的感兴趣区域进行注释和评估。使用重复性系数（RC）和RC%总结了每种分析图像类型的ROI体积重复性和平均ROI ADC。共有189名受试者参加了这项研究。在40例初步同意的患者中，15例男性接受了2次mpMRI检查并完成了研究。在11名受试者中确定了外周区tROI。11例受试者中有8例的肿瘤ROI体积小于0.5 mL。11/15例受试者的基线-重复研究之间的PI-RADS类别相同，4/15例受试者相差1分。外周区tROI体积RC（RC%）在轴向T2加权上为233 mm 3（71%），在ADC上为422 mm 3（112%），在动态对比增强减影上为488 mm 3（119%）。PZ tROI的表观扩散系数ROI平均RC（RC%）为447 × 10−6 mm−2/s（42%），正常PZ为471 × 10−6 mm−2/s（30%）。观察到系列间tROI体积的可重复性存在显著差异（P < 0.005）。tROI ADC的平均ADC RC%低于体积RC%（P < 0.05）。PI-RADS v2总体评估具有高度可重复性。多参数磁共振成像序列在体积测量可重复性方面不同。与ADC中的tROI体积相比，平均tROI ADC更具可重复性。前列腺ADC的重复性与其他腹部器官相当。
Supplemental digital content is available in the text. The aim of this study was to evaluate the repeatability of a region of interest (ROI) volume and mean apparent diffusion coefficient (ADC) in standard-of-care 3 T multiparametric magnetic resonance imaging (mpMRI) of the prostate obtained with the use of endorectal coil. This prospective study was Health Insurance Portability and Accountability Act compliant, with institutional review board approval and written informed consent. Men with confirmed or suspected treatment-naive prostate cancer scheduled for mpMRI were offered a repeat mpMRI within 2 weeks. Regions of interest corresponding to the whole prostate gland, the entire peripheral zone (PZ), normal PZ, and suspected tumor ROI (tROI) on axial T2-weighted, dynamic contrast-enhanced subtract, and ADC images were annotated and assessed using Prostate Imaging Reporting and Data System (PI-RADS) v2. Repeatability of the ROI volume for each of the analyzed image types and mean ROI ADC was summarized with repeatability coefficient (RC) and RC%. A total of 189 subjects were approached to participate in the study. Of 40 patients that gave initial agreement, 15 men underwent 2 mpMRI examinations and completed the study. Peripheral zone tROIs were identified in 11 subjects. Tumor ROI volume was less than 0.5 mL in 8 of 11 subjects. PI-RADS categories were identical between baseline-repeat studies in 11/15 subjects and differed by 1 point in 4/15. Peripheral zone tROI volume RC (RC%) was 233 mm3 (71%) on axial T2-weighted, 422 mm3 (112%) on ADC, and 488 mm3 (119%) on dynamic contrast-enhanced subtract. Apparent diffusion coefficient ROI mean RC (RC%) were 447 × 10−6 mm−2/s (42%) in PZ tROI and 471 × 10−6 mm−2/s (30%) in normal PZ. Significant difference in repeatability of the tROI volume across series was observed (P < 0.005). The mean ADC RC% was lower than volume RC% for tROI ADC (P < 0.05). PI-RADS v2 overall assessment was highly repeatable. Multiparametric magnetic resonance imaging sequences differ in volume measurement repeatability. The mean tROI ADC is more repeatable compared with tROI volume in ADC. Repeatability of prostate ADC is comparable with that in other abdominal organs.