Deficits in Physical Function Among Young Childhood Cancer Survivors
Deficits in Physical Function Among Young Childhood Cancer Survivors
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DOI：
10.1200/jco.2012.47.8081
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发表时间：
2013-08-01
影响因子：
45.3
通讯作者：
Ness, Kirsten K.
中科院分区：
文献类型：
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作者：
Hoffman, Megan C.;Mulrooney, Daniel A.;Ness, Kirsten K.
目的儿童癌症幸存者(CCSS)有身体残疾的风险。这项调查的目的是描述和比较CCSS和一组18岁的兄弟姐妹的体能表现，并确定诊断、治疗和体力活动水平是否与较低的表现分数相关。方法从确诊起5年的CCSS和兄弟姐妹对照组被招募并评估力量、活动能力和健康状况。结果CCS(n=183；平均年龄+/-标准差[SD]，13.5+/-2.5岁；53%男性)在下肢力量测试、计时起跳(TUG)试验和6分钟步行(6 MW)试验中得分低于兄弟姐妹(n=147；平均年龄+/-SD，13.4+/-2.4岁；50%男性)。在中枢神经系统肿瘤和骨和软组织肉瘤的幸存者中，力量测试得分最低(得分+/-SD：中枢神经系统肿瘤，76.5+/-4.7；肉瘤67.1+/-7.2v同胞，87.3+/-2.4牛顿米力量，每秒90；P=0.04和0.01)；在拖拽试验中，CNS肿瘤幸存者(得分+/-SD：5.1+/-0.1v同胞，4.4+/-0.1秒；P<；.001)和6 mW测试(得分+/-SD：533.3+/-15.6v兄弟姐妹，594.1+/-8.3m；P<；.001)。结论CCSS可能存在潜在的生理缺陷，干扰功能，而这些缺陷不能通过参加常规体力活动完全克服。除了通常的咨询外，这些幸存者可能还需要转介进行专门的运动干预，以保持身体活跃。(C)美国临床肿瘤学会2013年
PurposeChildhood cancer survivors (CCSs) are at risk for physical disability. The aim of this investigation was to characterize and compare physical performance among CCSs and a group of siblings age < 18 years and determine if diagnosis, treatment, and physical activity levels were associated with lower performance scores.MethodsCCSs >= 5 years from diagnosis and a sibling comparison group were recruited and evaluated for strength, mobility, and fitness. Physical performance measures were compared in regression models between survivors and siblings by diagnosis and among survivors by treatment exposures and physical activity levels.ResultsCCSs (n = 183; mean age +/- standard deviation [SD], 13.5 +/- 2.5 years; 53% male) scored lower than siblings (n = 147; mean age +/- SD, 13.4 +/- 2.4 years; 50% male) on lower-extremity strength testing, the timed up-and-go (TUG) test, and the 6-minute walk (6MW) test, despite reporting similar levels and types of habitual physical activity. The lowest scores were prevalent among survivors of CNS tumors and bone and soft tissue sarcomas on strength testing (score +/- SD: CNS tumors, 76.5 +/- 4.7; sarcoma 67.1 +/- 7.2 v siblings, 87.3 +/- 2.4 Newton-meters quadricep strength at 90 per second; P = .04 and .01, respectively) and among CNS tumor survivors on the TUG (score +/- SD: 5.1 +/- 0.1 v siblings, 4.4 +/- 0.1 seconds; P < .001) and 6MW tests (score +/- SD: 533.3 +/- 15.6 v siblings, 594.1 +/- 8.3 m; P < .001).ConclusionCCSs may have underlying physiologic deficits that interfere with function that cannot be completely overcome by participation in regular physical activity. These survivors may need referral for specialized exercise interventions in addition to usual counseling to remain physically active. (C) 2013 by American Society of Clinical Oncology